ArticleGenome research2012
Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 117 citations in OpenAlex.
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Segmented filamentous bacteria are worldwide human gut commensals.Nature communications · 2026Article
- Sequencing and Analysis of Chicken Segmented Filamentous Bacteria Genome Revealed Unique Avian-Specific Features.Microorganisms · 2026Article
- Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament development.Nature communications · 2025Article
- Unlocking Probiotic Potential: Physicochemical Approaches to Evaluate Probiotic Bacterial Adhesion Potential to the Intestinal Tract.Molecular nutrition & food research · 2025Article
- Abundance of single filamentous bacteria, and expression of differentiated Th17 cells, their signature cytokine IL-17 A, and retinoic acid receptor are predictive of poor rotavirus vaccine take.Virology journal · 2025Article
- Layer segmented filamentous bacteria colonize and impact gut health of broiler chickens.mSphere · 2024Article
- Fourteen years of cellular deconvolution: methodology, applications, technical evaluation and outstanding challenges.Nucleic acids research · 2024Review
- Segmented filamentous bacteria-based treatment to elicit protection againstFrontiers in microbiology · 2023Article
- Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology.Journal of inflammation (London, England) · 2022Review
- Comparative genome analysis of commensal segmented filamentous bacteria (SFB) from turkey and murine hosts reveals distinct metabolic features.BMC genomics · 2022Article
- Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel.Nature communications · 2022Article
- Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors.Cell host & microbe · 2021Article
- Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.Open biology · 2021Article
- The Role of Segmented Filamentous Bacteria in Immune Barrier Maturation of the Small Intestine at Weaning.Frontiers in nutrition · 2021Review
- Heat Stress Alters the Intestinal Microbiota and Metabolomic Profiles in Mice.Frontiers in microbiology · 2021Article
- Genome sequence of segmented filamentous bacteria present in the human intestine.Communications biology · 2020Article
- Distribution and Strain Diversity of Immunoregulating Segmented Filamentous Bacteria in Human Intestinal Lavage Samples.Microbial ecology · 2020Article
- Calcium transcriptionally regulates movement, recombination and other functions of Xylella fastidiosa under constant flow inside microfluidic chambers.Microbial biotechnology · 2020Article
- Development of the Ileal Microbiota in Three Broiler Breeds.Frontiers in veterinary science · 2020Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Segmented filamentous bacteria (SFB) are host-specific intestinal symbionts that comprise a distinct clade within the Clostridiaceae, designated Candidatus Arthromitus. SFB display a unique life cycle within the host, involving differentiation into multiple cell types. The latter include filaments that attach intimately to intestinal epithelial cells, and from which "holdfasts" and spores develop. SFB induce a multifaceted immune response, leading to host protection from intestinal pathogens. Cultivation resistance has hindered characterization of these enigmatic bacteria. In the present study, we isolated five SFB filaments from a mouse using a microfluidic device equipped with laser tweezers, generated genome sequences from each, and compared these sequences with each other, as well as to recently published SFB genome sequences. Based on the resulting analyses, SFB appear to be dependent on the host for a variety of essential nutrients. SFB have a relatively high abundance of predicted proteins devoted to cell cycle control and to envelope biogenesis, and have a group of SFB-specific autolysins and a dynamin-like protein. Among the five filament genomes, an average of 8.6% of predicted proteins were novel, including a family of secreted SFB-specific proteins. Four ADP-ribosyltransferase (ADPRT) sequence types, and a myosin-cross-reactive antigen (MCRA) protein were discovered; we hypothesize that they are involved in modulation of host responses. The presence of polymorphisms among mouse SFB genomes suggests the evolution of distinct SFB lineages. Overall, our results reveal several aspects of SFB adaptation to the mammalian intestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.