Trial reportSleep & breathing = Schlaf & Atmung2013
The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers.
Trial report in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06480253 (Variation of Cerebral Blood Flow Depending on the Interface Chosen During Continuous Positive Airway Pressure Ventilation), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Variation of Cerebral Blood Flow Depending on the Interface Chosen During Continuous Positive Airway Pressure Ventilation
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Does helmet CPAP reduce carotid flow compared to oronasal mask CPAP? A randomized cross-over trial in healthy subjects.Internal and emergency medicine · 2025Trial
- Positive pressure ventilation improves oxygen saturation at altitude during recreational aviation: A pilot study.Physiological reports · 2025Trial
- Positive end-expiratory pressure impact on cardiac output and cerebral hemodynamics in newborns.European journal of pediatrics · 2025Article
- An implantable system to restore hemodynamic stability after spinal cord injury.Nature medicine · 2025Article
- Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study.Frontiers in medical technology · 2025Article
- Variability in Intracranial Vessel Diameters and Considerations for Neurovascular Models: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Acute cerebrovascular event in a COVID-19 positive patient immediately after commencing non-invasive ventilation.BMJ case reports · 2020Article
- Combined lung and brain ultrasonography for an individualized "brain-protective ventilation strategy" in neurocritical care patients with challenging ventilation needs.Critical ultrasound journal · 2018Article
- Cerebral hemodynamic changes in obstructive sleep apnea syndrome after continuous positive airway pressure treatment.Sleep & breathing = Schlaf & Atmung · 2013Article
- The relationship between cephalometric carotid artery calcification and Framingham Risk Score profile in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeContinuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no widespread accepted protocol. We studied the physiologic influence of CPAP on CBF using a method integrating arterial diameter and flow velocity (FV) measurements obtained for each vessel supplying blood to the brain.
methodsFV and lumen diameter of the left and right internal carotid, vertebral, and middle cerebral arteries were measured using duplex Doppler ultrasound with and without CPAP at 15 cm H(2)O, applied in a random order. Transcutaneous carbon dioxide (PtcCO(2)), heart rate (HR), blood pressure (BP), and oxygen saturation were monitored. Results were compared with a theoretical prediction of CBF change based on the effect of partial pressure of carbon dioxide on CBF.
resultsData were obtained from 23 healthy volunteers (mean ± SD; 12 male, age 25.1 ± 2.6 years, body mass index 21.8 ± 2.0 kg/m(2)). The mean experimental and theoretical CBF decrease under CPAP was 12.5 % (p < 0.001) and 11.9 % (p < 0.001), respectively. The difference between experimental and theoretical CBF reduction was not statistically significant (3.84 ± 79 ml/min, p = 0.40). There was a significant reduction in PtcCO(2) with CPAP (p = <0.001) and a significant increase in mean BP (p = 0.0017). No significant change was observed in SaO(2) (p = 0.21) and HR (p = 0.62).
conclusionDuplex Doppler ultrasound measurements of arterial diameter and FV allow for a noninvasive bedside estimation of CBF. CPAP at 15 cm H(2)O significantly decreased CBF in healthy awake volunteers. This effect appeared to be mediated predominately through the hypocapnic vasoconstriction coinciding with PCO(2) level reduction. The results suggest that CPAP should be used cautiously in patients with unstable cerebral hemodynamics.
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