ArticleNature communications2012
Transient activation of specific neurons in mice by selective expression of the capsaicin receptor.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Recruitment of specific dopamine neuron sub-circuits by opioids.Addiction neuroscience · 2025Article
- Age-specific regulation of sociability by hypothalamic Agrp neurons.Current biology : CB · 2025Article
- A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease.Science advances · 2025Article
- Hematological and thermographical changes in rat's model exposed to long-term RF modulated signals.Open veterinary journal · 2024Article
- Methodology for Studying Hypothalamic Regulation of Feeding Behaviors.Methods and protocols · 2024Review
- Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration.Communications biology · 2024Article
- The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson's disease.Journal of neuroinflammation · 2022Article
- Dopamine systems and biological rhythms: Let's get a move on.Frontiers in integrative neuroscience · 2022Review
- Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis.Frontiers in immunology · 2022Article
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- Ultrapotent chemogenetics for research and potential clinical applications.Science (New York, N.Y.) · 2019Article
- Regulation of substrate utilization and adiposity by Agrp neurons.Nature communications · 2019Article
- Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo.Experimental & molecular medicine · 2018Article
- Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.Experimental & molecular medicine · 2018Article
- Chemogenetic Tools for Causal Cellular and Neuronal Biology.Physiological reviews · 2018Review
- Sexual congruency in the connectome and translatome of VTA dopamine neurons.Scientific reports · 2017Article
- Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics.Nature protocols · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The ability to control the electrical activity of a neuronal subtype is a valuable tool in deciphering the role of discreet cell populations in complex neural circuits. Recent techniques that allow remote control of neurons are either labor intensive and invasive or indirectly coupled to neural electrical potential with low temporal resolution. Here we show the rapid, reversible and direct activation of genetically identified neuronal subpopulations by generating two inducible transgenic mouse models. Confined expression of the capsaicin receptor, TRPV1, allows cell-specific activation after peripheral or oral delivery of ligand in freely moving mice. Capsaicin-induced activation of dopaminergic or serotonergic neurons reversibly alters both physiological and behavioural responses within minutes, and lasts ~10 min. These models showcase a robust and remotely controllable genetic tool that modulates a distinct cell population without the need for invasive and labour-intensive approaches.
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Registered trials
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