ArticleThe Journal of biological chemistry2012
Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signaling.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice.Molecular neurodegeneration · 2025Article
- ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function.Nature communications · 2023Article
- Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke.Research (Washington, D.C.) · 2023Article
- Transcriptomic architecture of nuclei in the marmoset CNS.Nature communications · 2022Article
- Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex.Nature neuroscience · 2022Article
- Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia.Journal of cellular and molecular medicine · 2022Article
- Computational Methods to Identify Cell-Fate Determinants, Identity Transcription Factors, and Niche-Induced Signaling Pathways for Stem Cell Research.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Manipulating oligodendrocyte intrinsic regeneration mechanism to promote remyelination.Cellular and molecular life sciences : CMLS · 2021Review
- Conditional Deletion of Foxg1 Alleviates Demyelination and Facilitates Remyelination via the Wnt Signaling Pathway in Cuprizone-Induced Demyelinated Mice.Neuroscience bulletin · 2021Article
- SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.Nature communications · 2020Article
- Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.Cell reports · 2020Article
- The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled.eLife · 2016Article
- A new in vitro mouse oligodendrocyte precursor cell migration assay reveals a role for integrin-linked kinase in cell motility.BMC neuroscience · 2016Article
- A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells.Frontiers in cellular neuroscience · 2016Article
- P2X7 receptors and Fyn kinase mediate ATP-induced oligodendrocyte progenitor cell migration.Purinergic signalling · 2015Article
- The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.Nature communications · 2015Article
- Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.PloS one · 2014Article
- An anti-sulfatide antibody O4 immunoprecipitates sulfatide rafts including Fyn, Lyn and the G protein α subunit in rat primary immature oligodendrocytes.Glycoconjugate journal · 2013Article
- TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.The Journal of biological chemistry · 2013Article
- Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligodendrocyte precursor cells (OPCs) are a unique type of glia that are responsible for the myelination of the central nervous system. OPC migration is important for myelin formation during central nervous system development and repair. However, the precise extracellular and intracellular mechanisms that regulate OPC migration remain elusive. Slits were reported to regulate neurodevelopmental processes such as migration, adhesion, axon guidance, and elongation through binding to roundabout receptors (Robos). However, the potential roles of Slits/Robos in oligodendrocytes remain unknown. In this study, Slit2 was found to be involved in regulating the dispersal of OPCs through the association between Robo1 and Fyn. Initially, we examined the expression of Robos in OPCs both in vitro and in vivo. Subsequently, the Boyden chamber assay showed that Slit2 could inhibit OPC migration. RoboN, a specific inhibitor of Robos, could significantly attenuate this effect. The effects were confirmed through the explant migration assay. Furthermore, treating OPCs with Slit2 protein deactivated Fyn and increased the level of activated RhoA-GTP. Finally, Fyn was found to form complexes with Robo1, but this association was decreased after Slit2 stimulation. Thus, we demonstrate for the first time that Slit2 regulates the dispersal of oligodendrocyte precursor cells through Fyn and RhoA signaling.
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