ReviewThe EMBO journal2012
Mechanisms regulating epidermal stem cells.
Review in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 77 citations in OpenAlex.
- Cellular and molecular changes in the skin driving increased nociception and pain during burn injury and repair.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Article
- Review
- Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche.Nature communications · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2021Article
- GDF-5 promotes epidermal stem cells proliferation via Foxg1-cyclin D1 signaling.Stem cell research & therapy · 2021Article
- Review
- Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair.Advances in wound care · 2020Article
- Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing.Experimental and therapeutic medicine · 2020Article
- Single-Cell ID-seq Reveals Dynamic BMP Pathway Activation Upstream of the MAF/MAFB-Program in Epidermal Differentiation.iScience · 2018Article
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.Nature communications · 2018Article
- Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.Oncotarget · 2016Article
- LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development.Development (Cambridge, England) · 2016Article
- Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation.Stem cell reports · 2016Article
- Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions.International journal of molecular medicine · 2016Article
- Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells.International journal of oral science · 2015Review
- Epigenetic control of skin and hair regeneration after wounding.Experimental dermatology · 2015Review
- Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.Genes & development · 2015Article
- Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.Cell cycle (Georgetown, Tex.) · 2015Article
- MicroRNAs and p63 in epithelial stemness.Cell death and differentiation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin epidermis contains different appendages such as the hair follicle and the sebaceous glands. Recent studies demonstrated that several types of stem cells (SCs) exist in different niches within the epidermis and maintain discrete epidermal compartments, but the exact contribution of each SC populations under physiological conditions is still unclear. In addition, the precise mechanisms controlling the balance between proliferation and differentiation of epidermal SC still remain elusive. Recent studies provide new insights into these important questions by showing the contribution of hair follicle SC to the sebaceous lineage and the importance of chromatin modifications and micro-RNAs (miRs) in regulating epidermal SCs renewal and differentiation. In this review, we will discuss the importance of these papers to our understanding of the mechanisms that control epidermal SC functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.