ReviewAdvanced drug delivery reviews2012
Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues.
Review in Advanced drug delivery reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Glutathione-Triggered Nitrite Release From Organic Nitrites Enhances Nitric Oxide Bioavailability in Mammalian Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Confined Micellar Environments Modulate Thiol Reactivity and Nitrite Release From 4-Nitronaphthalimide Nitric Oxide Prodrugs.Chemistry, an Asian journal · 2026Article
- Titanium Implants Functionalized with Zoledronic Acid Associated with Ruterpy Accelerate Peri-Implant Repair in Healthy and Osteoporotic Rats.Biomimetics (Basel, Switzerland) · 2025Article
- Ultrasound-Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric-Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nitric Oxide-Releasing Nanoscale Metal-Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.Journal of nanobiotechnology · 2025Review
- Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria.Advanced healthcare materials · 2024Article
- Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Antibacterial gas therapy: Strategies, advances, and prospects.Bioactive materials · 2023Review
- Nitric Oxide (NO) as a Reagent for Topochemical Framework Transformation and Controlled NO Release in Covalent Organic Frameworks.Journal of the American Chemical Society · 2023Article
- Injectable polysaccharide hydrogels as localized nitric oxide delivery formulations.Advanced materials technologies · 2023Article
- Local delivery of gaseous signaling molecules for orthopedic disease therapy.Journal of nanobiotechnology · 2023Review
- Delivery of nitric oxide-releasing silica nanoparticles forNeural regeneration research · 2022Article
- Nitric Oxide-Releasing Platforms for Treating Cardiovascular Disease.Pharmaceutics · 2022Review
- A novel atmospheric-pressure air plasma jet for wound healing.International wound journal · 2022Article
- Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook.Journal of functional biomaterials · 2021Review
- Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy.International journal of molecular sciences · 2021Review
- Development of Antimicrobial Nitric Oxide-Releasing Fibers.Pharmaceutics · 2021Article
- Nitric Oxide-Releasing Hyaluronic Acid as an Antibacterial Agent for Wound Therapy.Biomacromolecules · 2021Article
- Nitrate-Functionalized poly(ε-Caprolactone) Small-Diameter Vascular Grafts Enhance Vascular RegenerationFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.