ArticlePsychological medicine2012
Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide.
Article in Psychological medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of Childhood Maltreatment With Suicide Behaviors Among Young People: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Exposure to parental psychopathology and offspring's risk of suicide-related thoughts and behaviours: a systematic review.Epidemiology and psychiatric sciences · 2019Pooled it
- A Meta-Analysis of Universal School-Based Prevention Programs for Anxiety and Depression in Children.Clinical child and family psychology review · 2018Pooled it
- Independent contribution of emotion dysregulation to suicide attempts in adolescents beyond the role of depressive symptoms.Scientific reports · 2026Article
- Suicide risk among individuals admitted to an acute psychiatric ward: clinical characteristics, attachment pattern and dignity perception.Frontiers in psychiatry · 2026Article
- Sex Differences in Behavioral and Psychopathological Trajectories From Late Childhood to Early Adolescence: Implications for Suicidality Risk.Depression and anxiety · 2025Article
- Profiles of Risk for Self-injurious Thoughts and Behaviors Among System-Impacted Girls of Color.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- A Stress Protein-Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress.The international journal of neuropsychopharmacology · 2023Article
- Maladaptive personality traits may link childhood trauma history to current internalizing symptoms.Scandinavian journal of psychology · 2022Article
- The mediating role of internalizing and externalizing symptoms in the relationship between childhood trauma and suicidality among adolescents: a structural equation model.Child and adolescent psychiatry and mental health · 2021Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Characteristics and Circumstances Associated with Work-Related Suicides from the National Violent Death Reporting System, 2013-2017.International journal of environmental research and public health · 2021Article
- Identification of Suicidal Ideation in theFrontiers in artificial intelligence · 2021Article
- Developmental pathways from child maltreatment to adolescent suicide-related behaviors: The internalizing and externalizing comorbidity hypothesis.Development and psychopathology · 2020Article
- Atypical Cortical Activation During Risky Decision Making in Disruptive Behavior Disordered Youths With Histories of Suicidal Ideation.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: mediation by child psychiatric symptoms.Epidemiology and psychiatric sciences · 2019Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Childhood adversity and midlife suicidal ideation.Psychological medicine · 2017Article
- Suicide and suicidal behaviour.Lancet (London, England) · 2016Review
- Investigating epigenetic consequences of early-life adversity: some methodological considerations.European journal of psychotraumatology · 2016Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
backgroundSuicidal behavior is frequently associated with a history of childhood abuse yet it remains unclear precisely how early life adversity may increase suicide risk later in life. As such, our aim was to examine whether lifetime trajectories of disruptiveness and anxiousness trait dysregulation explain the association between childhood adversity and suicidal behavior; and moreover, to test the potential modifying effects of mental disorders on these associations.
methodA sample of 1776 individuals from a prospective school-based cohort followed longitudinally for over 22 years was investigated. We tested the influence of disruptiveness and anxiousness trajectories from age 6 to 12 years on the association between childhood adversity (i.e. sexual and physical abuse) and history of suicide attempts (SA) using logistic regression models. Both adolescent externalizing and internalizing Axis I disorders and gender were tested as potential modifiers of these associations.
resultsFour distinct longitudinal trajectories were identified for both disruptiveness and anxiousness. The high disruptiveness trajectory accounted for the association between childhood adversity and SA, but only for females. The high anxiousness trajectory also explained the association between adversity and SA; however, in this case it was not sex but mental disorders that influenced the potency of the mediating effect. More specifically, anxiousness fully explained the effect of adversity on SA in the presence of externalizing disorders, whereas in the absence of these disorders, this effect was significantly attenuated.
conclusionsThis study provides evidence that both disruptiveness and anxiousness play an important role in explaining the relationship between childhood adversity and SA.
Indexed as
Identifiers
22433421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.