ArticleBMC genomics2012
Genome-wide dynamic transcriptional profiling in Clostridium beijerinckii NCIMB 8052 using single-nucleotide resolution RNA-Seq.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- Clostridium beijerinckii displays a soluble [FeFe]-hydrogenase/formate dehydrogenase enzyme complex that links H2 and CO2 metabolism.The Biochemical journal · 2026Article
- Analysis of Microbial Community Structure and Cultivation Performance Assessment inJournal of fungi (Basel, Switzerland) · 2025Article
- Identification and Validation of Reference Genes inFrontiers in microbiology · 2021Article
- Changes in efflux pump activity of Clostridium beijerinckii throughout ABE fermentation.Applied microbiology and biotechnology · 2021Article
- Ferrous-Iron-Activated Transcriptional Factor AdhR Regulates Redox Homeostasis inApplied and environmental microbiology · 2020Article
- Control of solvent production by sigma-54 factor and the transcriptional activator AdhR in Clostridium beijerinckii.Microbial biotechnology · 2020Article
- Transcriptomic and Phenotypic Analysis of aFrontiers in microbiology · 2020Article
- Genomic reconstruction of σBMC genomics · 2019Article
- Acidogenesis, solventogenesis, metabolic stress response and life cycle changes in Clostridium beijerinckii NRRL B-598 at the transcriptomic level.Scientific reports · 2019Article
- Article
- A transcriptional response ofBiotechnology for biofuels · 2019Article
- The Draft Genome Sequence of a Novel High-Efficient Butanol-Producing Bacterium Clostridium Diolis Strain WST.Current microbiology · 2018Article
- Transcription profiling of butanol producer Clostridium beijerinckii NRRL B-598 using RNA-Seq.BMC genomics · 2018Article
- Genome and transcriptome of the natural isopropanol producer Clostridium beijerinckii DSM6423.BMC genomics · 2018Article
- Mathematical modelling of clostridial acetone-butanol-ethanol fermentation.Applied microbiology and biotechnology · 2017Review
- Strategies for improved isopropanol-butanol production by aBiotechnology for biofuels · 2017Article
- Sigma Factor Regulated Cellular Response in a Non-solvent ProducingFrontiers in microbiology · 2017Article
- Transcriptional analysis of degenerate strain Clostridium beijerinckii DG-8052 reveals a pleiotropic response to CaCOScientific reports · 2016Article
- Dam and Dcm methylations prevent gene transfer into Clostridium pasteurianum NRRL B-598: development of methods for electrotransformation, conjugation, and sonoporation.Biotechnology for biofuels · 2016Article
- A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication.BMC genomics · 2015Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridium beijerinckii is a prominent solvent-producing microbe that has great potential for biofuel and chemical industries. Although transcriptional analysis is essential to understand gene functions and regulation and thus elucidate proper strategies for further strain improvement, limited information is available on the genome-wide transcriptional analysis for C. beijerinckii.
resultsThe genome-wide transcriptional dynamics of C. beijerinckii NCIMB 8052 over a batch fermentation process was investigated using high-throughput RNA-Seq technology. The gene expression profiles indicated that the glycolysis genes were highly expressed throughout the fermentation, with comparatively more active expression during acidogenesis phase. The expression of acid formation genes was down-regulated at the onset of solvent formation, in accordance with the metabolic pathway shift from acidogenesis to solventogenesis. The acetone formation gene (adc), as a part of the sol operon, exhibited highly-coordinated expression with the other sol genes. Out of the > 20 genes encoding alcohol dehydrogenase in C. beijerinckii, Cbei_1722 and Cbei_2181 were highly up-regulated at the onset of solventogenesis, corresponding to their key roles in primary alcohol production. Most sporulation genes in C. beijerinckii 8052 demonstrated similar temporal expression patterns to those observed in B. subtilis and C. acetobutylicum, while sporulation sigma factor genes sigE and sigG exhibited accelerated and stronger expression in C. beijerinckii 8052, which is consistent with the more rapid forespore and endspore development in this strain. Global expression patterns for specific gene functional classes were examined using self-organizing map analysis. The genes associated with specific functional classes demonstrated global expression profiles corresponding to the cell physiological variation and metabolic pathway switch.
conclusionsThe results from this work provided insights for further C. beijerinckii strain improvement employing system biology-based strategies and metabolic engineering approaches.
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