ArticleParasites & vectors2012
Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis.
Article in Parasites & vectors, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.The Cochrane database of systematic reviews · 2016Pooled it
- Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Pooled it
- Efficacy of Intensified Hygiene Measures with or without the Addition of Doxycycline in the Management of Filarial Lymphedema: A Randomized Double-Blind, Placebo-Controlled Clinical Trial in Tanzania.The American journal of tropical medicine and hygiene · 2024Trial
- Oral doxycycline for the prevention of postoperative trachomatous trichiasis in Ethiopia: a randomised, double-blind, placebo-controlled trial.The Lancet. Global health · 2018Trial
- Acceptability of test and treat with doxycycline against Onchocerciasis in an area of persistent transmission in Massangam Health District, Cameroon.PLoS neglected tropical diseases · 2023Article
- Onchocerciasis drug development: from preclinical models to humans.Parasitology research · 2021Review
- The Wolbachia Symbiont: Here, There and Everywhere.Results and problems in cell differentiation · 2020Article
- Article
- AWZ1066S, a highly specific anti-Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Onchodermatitis: Where Are We Now?Tropical medicine and infectious disease · 2018Review
- The Search for an Efficient Black Fly Trap for Xenomonitoring of Onchocerciasis.Journal of parasitology research · 2018Review
- Onchocerciasis, an undiagnosed disease in Mozambique: identifying research opportunities.Parasites & vectors · 2016Article
- Relationship between oral declaration on adherence to ivermectin treatment and parasitological indicators of onchocerciasis in an area of persistent transmission despite a decade of mass drug administration in Cameroon.Parasites & vectors · 2015Article
- Situation analysis of parasitological and entomological indices of onchocerciasis transmission in three drainage basins of the rain forest of South West Cameroon after a decade of ivermectin treatment.Parasites & vectors · 2015Article
- Control, elimination, and eradication of river blindness: scenarios, timelines, and ivermectin treatment needs in Africa.PLoS neglected tropical diseases · 2015Article
- Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.PLoS neglected tropical diseases · 2015Article
- Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.International journal for parasitology. Drugs and drug resistance · 2014Article
- Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.PloS one · 2014Article
- Chemotherapy in the treatment, control, and elimination of human onchocerciasis.Research and reports in tropical medicine · 2014Review
- Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.Parasitology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-Wolbachia treatment with doxycycline is effective in sterilising and killing adult Onchocerca volvulus nematodes, proving superior to ivermectin and of great potential as an alternative approach for the treatment and control of onchocerciasis, particularly in areas of Loa loa co-endemicity. Nevertheless, the length of the required treatment poses potential logistical problems and risk of poor compliance, raising a barrier to the use of doxycycline in Mass Drug Administration (MDA) strategies. In 2007 and 2008 a feasibility trial of community-directed treatment with doxycycline was carried out in two health districts in Cameroon, co-endemic for O. volvulus and L. loa. With 17,519 eligible subjects, the therapeutic coverage was 73.8% with 97.5% compliance, encouraging the feasibility of using doxycycline community-directed delivery in restricted populations of this size. The current study evaluated the effectiveness of this community-directed delivery of doxycycline four years after delivery.
findingsInfection with O. volvulus was evaluated by skin biopsy and nodule palpation. Of the 507 subjects recruited, 375 had completed the treatment with doxycycline followed by one or two rounds of annual ivermectin MDA and 132 received one or two rounds of annual ivermectin MDA alone. Statistically significant lower microfilarial prevalence (17.0% [doxycycline plus ivermectin group], 27.0% [ivermectin only group], p = 0.014) and load (p = 0.012) were found in people that had received doxycycline followed by ivermectin compared to those who received ivermectin only.
conclusionsThis study demonstrates the long-term effectiveness of doxycycline treatment delivered with a community-directed strategy even when evaluated four years after delivery in an area of ongoing transmission. This finding shows that a multi-week course of treatment is not a barrier to community-delivery of MDA in restricted populations of this size and supports its implementation to compliment existing control strategies for onchocerciasis, where needed.
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