ArticleNano letters2012
Lipid-based passivation in nanofluidics.
Article in Nano letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microfluidic Biosensors: Enabling Advanced Disease Detection.Sensors (Basel, Switzerland) · 2025Review
- Lifting the Concentration Limit of Mass Photometry by PEG Nanopatterning.Nano letters · 2024Article
- Article
- Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Ligand functionalization of titanium nanopattern enables the analysis of cell-ligand interactions by super-resolution microscopy.Nature protocols · 2022Review
- Label-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles.Nature methods · 2022Article
- Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles.Nature communications · 2021Article
- Lipid bilayer coatings for rapid enzyme-linked immunosorbent assay.Applied materials today · 2021Article
- The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA.Nucleic acids research · 2021Article
- Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion.Biochemical and biophysical research communications · 2020Article
- Lipid-Bicelle-Coated Microfluidics for Intracellular Delivery with Reduced Fouling.ACS applied materials & interfaces · 2020Article
- Alpha-Synuclein Modulates the Physical Properties of DNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction.Molecular microbiology · 2018Article
- Motor-like DNA motion due to an ATP-hydrolyzing protein under nanoconfinement.Scientific reports · 2018Article
- Non-lithographic nanofluidic channels with precisely controlled circular cross sections.RSC advances · 2018Article
- Hairpins in the conformations of a confined polymer.Biomicrofluidics · 2018Article
- Optimizing the Performance of Supported Lipid Bilayers as Cell Culture Platforms Based on Extracellular Matrix Functionalization.ACS omega · 2017Article
- DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels.Nucleic acids research · 2016Article
- High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.Langmuir : the ACS journal of surfaces and colloids · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stretching DNA in nanochannels is a useful tool for direct, visual studies of genomic DNA at the single molecule level. To facilitate the study of the interaction of linear DNA with proteins in nanochannels, we have implemented a highly effective passivation scheme based on lipid bilayers. We demonstrate virtually complete long-term passivation of nanochannel surfaces to a range of relevant reagents, including streptavidin-coated quantum dots, RecA proteins, and RecA-DNA complexes. We show that the performance of the lipid bilayer is significantly better than that of standard bovine serum albumin-based passivation. Finally, we show how the passivated devices allow us to monitor single DNA cleavage events during enzymatic degradation by DNase I. We expect that our approach will open up for detailed, systematic studies of a wide range of protein-DNA interactions with high spatial and temporal resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.