Evidence map›Paper›PMID 22432116›Full record

ArticleDiabetes care2012

High burden of kidney disease in youth-onset type 2 diabetes.

Allison B Dart, Elizabeth A Sellers, Patricia J Martens, Claudio Rigatto, Marni D Brownell, Heather J Dean

Registry-linked trialOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06837181 (Studying the Presence of CFRD Complications With Thoughtful Recruitment), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  12. Observational
  13. Review
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  18. Kidney Considerations in Pediatric Obesity.Current obesity reports · 2023
    Review
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Allison B DartDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. adart@hsc.mb.ca
Elizabeth A Sellers
Patricia J Martens
Claudio Rigatto
Marni D Brownell
Heather J Dean
University of Manitoba · CAManitoba Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate renal outcomes and survival in youth with type 2 diabetes (T2DM) versus type 1 diabetes (T1DM) versus nondiabetic control subjects. RESEARCH DESIGN AND

methodsIn total, 342 prevalent youth (aged 1-18 years) with T2DM, 1,011 youth with T1DM, and 1,710 control subjects identified from 1986 to 2007 were anonymously linked to health care records housed at the Manitoba Centre for Health Policy to assess long-term outcomes using ICD codes.

resultsYouth with T2DM were found to have a fourfold increased risk of renal failure versus youth with T1DM. Risk factors associated with renal failure were renin angiotensin aldosterone system inhibitor use and albuminuria in adolescence. Compared with control subjects (age, sex, and postal code matched), youth with T2DM had a 23-fold increased risk of renal failure and a 39-fold increased risk of dialysis. Kaplan-Meier survival at 10 years was 91.4% in the type 2 diabetic group versus 99.5% in the type 1 diabetic group (P < 0.0001). Renal survival was 100% at 10 years in both groups. It decreased to 92.0% at 15 years and 55.0% at 20 years in the type 2 diabetic group but remained stable in the type 1 diabetic group (P < 0.0001).

conclusionsYouth with T2DM are at high risk of adverse renal outcomes and death. Albuminuria and angiotensin aldosterone system inhibitor use, which may be a marker of severity of disease, are associated with poor outcomes in early adulthood.

Indexed as

AdolescentAge of OnsetAlbuminuriaAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesFemaleHumansKaplan-Meier EstimateKidney Failure, ChronicMaleRenin-Angiotensin SystemRisk AssessmentAngiotensin-Converting Enzyme InhibitorsAntihypertensive Agents

Identifiers

PMID22432116
PMCPMC3357249
OpenAlexW2146684583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.