ArticlePloS one2012
Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
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- Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases.Journal of translational medicine · 2020Article
- Comments on 'Association of FcϵRIβ polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case-control studies'.Bioscience reports · 2020Article
- Investigation of the Possible Role of Tie2 Pathway andFrontiers in genetics · 2020Article
- Post-viral atopic airway disease: pathogenesis and potential avenues for intervention.Expert review of clinical immunology · 2019Review
- HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.Haematologica · 2017Article
- Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO.Allergy, asthma & immunology research · 2017Article
- Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy.Allergy, asthma & immunology research · 2017Article
- Article
- A BAYESIAN GRAPHICAL MODEL FOR GENOME-WIDE ASSOCIATION STUDIES (GWAS).The annals of applied statistics · 2016Article
- Pharmacogenomics of Prostaglandin and Leukotriene Receptors.Frontiers in pharmacology · 2016Review
- Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.PloS one · 2016Article
- In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia.The pharmacogenomics journal · 2015Article
- Novel genes in Human Asthma Based on a Mouse Model of Allergic Airway Inflammation and Human Investigations.Allergy, asthma & immunology research · 2014Article
- Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma.The Journal of allergy and clinical immunology · 2014Article
- Circulating survivin levels in healthy and asthmatic pregnancy.Reproductive biology and endocrinology : RB&E · 2014Article
- A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.Carcinogenesis · 2014Article
- Brain galanin system genes interact with life stresses in depression-related phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls.Respiratory research · 2014Article
- Epistatic effects of multiple receptor genes on pathophysiology of asthma - its limits and potential for clinical application.Medical science monitor : international medical journal of experimental and clinical research · 2014Review
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic studies indicate high number of potential factors related to asthma. Based on earlier linkage analyses we selected the 11q13 and 14q22 asthma susceptibility regions, for which we designed a partial genome screening study using 145 SNPs in 1201 individuals (436 asthmatic children and 765 controls). The results were evaluated with traditional frequentist methods and we applied a new statistical method, called bayesian network based bayesian multilevel analysis of relevance (BN-BMLA). This method uses bayesian network representation to provide detailed characterization of the relevance of factors, such as joint significance, the type of dependency, and multi-target aspects. We estimated posteriors for these relations within the bayesian statistical framework, in order to estimate the posteriors whether a variable is directly relevant or its association is only mediated.With frequentist methods one SNP (rs3751464 in the FRMD6 gene) provided evidence for an association with asthma (OR = 1.43(1.2-1.8); p = 3×10(-4)). The possible role of the FRMD6 gene in asthma was also confirmed in an animal model and human asthmatics.In the BN-BMLA analysis altogether 5 SNPs in 4 genes were found relevant in connection with asthma phenotype: PRPF19 on chromosome 11, and FRMD6, PTGER2 and PTGDR on chromosome 14. In a subsequent step a partial dataset containing rhinitis and further clinical parameters was used, which allowed the analysis of relevance of SNPs for asthma and multiple targets. These analyses suggested that SNPs in the AHNAK and MS4A2 genes were indirectly associated with asthma. This paper indicates that BN-BMLA explores the relevant factors more comprehensively than traditional statistical methods and extends the scope of strong relevance based methods to include partial relevance, global characterization of relevance and multi-target relevance.
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