ArticlePloS one2012
Molecular epidemiology of Neisseria meningitidis serogroup B in Brazil.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Ongoing Outbreak ofOpen forum infectious diseases · 2026Article
- Characterisation of Neisseria meningitidis cc11/ET-15 variant by whole genome sequencing.Memorias do Instituto Oswaldo Cruz · 2022Article
- Genomic surveillance of Neisseria meningitidis serogroup B invasive strains: Diversity of vaccine antigen types, Brazil, 2016-2018.PloS one · 2020Article
- Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.Infectious diseases (London, England) · 2018Article
- Bioengineered polyester beads co-displaying protein and carbohydrate-based antigens induce protective immunity against bacterial infection.Scientific reports · 2018Article
- A Predominant Clonal Thromboembolic Meningoencephalitis Group ofFrontiers in veterinary science · 2018Article
- The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire.Scientific reports · 2017Article
- Molecular characterization of Neisseria meningitidis isolates recovered from 11-19-year-old meningococcal carriers in Salvador, Brazil.PloS one · 2017Article
- Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease.Microbiology and molecular biology reviews : MMBR · 2013Review
- Phenotypic and genotypic characteristics of Neisseria meningitidis disease-causing strains in Argentina, 2010.PloS one · 2013Article
- Purpura fulminans in a child due to Neisseria meningitidis.Infection · 2012Article
- Evolutionary and genomic insights into meningococcal biology.Future microbiology · 2012Review
- Article
- Phase I safety and immunogenicity study of a Brazilian serogroup B vaccine.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
- Erratum issuedDunning Hotopp, Julie C [added]
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundNeisseria meningitidis serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988-2006) for study (n = 372).
methodsWe performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets fHbp and nadA.
resultsIn 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), fetA, and porB was significant but diversity was limited for nadA and fHbp. Between 1988 and 1996, the São Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, fHbp variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of nadA were similar to reference allele 1.
conclusionsA predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, fetA, and porB, but not in nadA and fHbp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.