ArticlePloS one2012
Membrane topology and predicted RNA-binding function of the 'early responsive to dehydration (ERD4)' plant protein.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
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- TMT proteomics analysis of a pseudocereal crop, quinoa (Frontiers in plant science · 2022Article
- Introgression ofCells · 2021Article
- The DUF221 domain-containing (DDP) genes identification and expression analysis in tomato under abiotic and phytohormone stress.GM crops & food · 2021Article
- Genome-Wide Identification and Expression Profiling of DUF221 Gene Family Provides New Insights Into Abiotic Stress Responses in Potato.Frontiers in plant science · 2021Article
- Identification of a molecular marker associated with lignotuber in Eucalyptus ssp.Scientific reports · 2020Article
- Cryo-EM structure of OSCA1.2 fromProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcriptome Analysis Reveals Key Cold-Stress-Responsive Genes in Winter Rapeseed (International journal of molecular sciences · 2019Article
- Cold Acclimation Improves the Desiccation Stress Resilience of Polar Strains ofFrontiers in microbiology · 2019Article
- Genome-wide analysis of maizePeerJ · 2019Article
- Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2.Nature communications · 2018Article
- The Discrepant and Similar Responses of Genome-Wide Transcriptional Profiles between Drought and Cold Stresses in Cassava.International journal of molecular sciences · 2017Article
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- Brassica RNA binding protein ERD4 is involved in conferring salt, drought tolerance and enhancing plant growth in Arabidopsis.Plant molecular biology · 2016Article
- Genome-wide survey and expression analysis of the OSCA gene family in rice.BMC plant biology · 2015Article
- High sequence variability, diverse subcellular localizations, and ecological implications of alkaline phosphatase in dinoflagellates and other eukaryotic phytoplankton.Frontiers in microbiology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional annotation of uncharacterized genes is the main focus of computational methods in the post genomic era. These tools search for similarity between proteins on the premise that those sharing sequence or structural motifs usually perform related functions, and are thus particularly useful for membrane proteins. Early responsive to dehydration (ERD) genes are rapidly induced in response to dehydration stress in a variety of plant species. In the present work we characterized function of Brassica juncea ERD4 gene using computational approaches. The ERD4 protein of unknown function possesses ubiquitous DUF221 domain (residues 312-634) and is conserved in all plant species. We suggest that the protein is localized in chloroplast membrane with at least nine transmembrane helices. We detected a globular domain of 165 amino acid residues (183-347) in plant ERD4 proteins and expect this to be posited inside the chloroplast. The structural-functional annotation of the globular domain was arrived at using fold recognition methods, which suggested in its sequence presence of two tandem RNA-recognition motif (RRM) domains each folded into βαββαβ topology. The structure based sequence alignment with the known RNA-binding proteins revealed conservation of two non-canonical ribonucleoprotein sub-motifs in both the putative RNA-recognition domains of the ERD4 protein. The function of highly conserved ERD4 protein may thus be associated with its RNA-binding ability during the stress response. This is the first functional annotation of ERD4 family of proteins that can be useful in designing experiments to unravel crucial aspects of stress tolerance mechanism.
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