ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Outbreaks of Pneumocystis pneumonia in 2 renal transplant centers linked to a single strain of Pneumocystis: implications for transmission and virulence.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 80 citations in OpenAlex.
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- Trends in the Epidemiology ofJournal of fungi (Basel, Switzerland) · 2023Review
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- Comparison of early and late Pneumocystis jirovecii Pneumonia in kidney transplant patients: the Korean Organ Transplantation Registry (KOTRY) Study.Scientific reports · 2022Article
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- Outbreak-Causing Fungi: Pneumocystis jirovecii.Mycopathologia · 2020Review
- Genetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis.Scientific reports · 2019Article
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- A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.Clinical microbiology reviews · 2018Review
- Diversity of Pneumocystis jirovecii Across Europe: A Multicentre Observational Study.EBioMedicine · 2017Observational
- Lifelong Prophylaxis With Trimethoprim-Sulfamethoxazole for Prevention of Outbreak ofTransplantation direct · 2017Article
- Review
- Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?Antimicrobial agents and chemotherapy · 2016Article
- Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.Nature communications · 2016Article
- [Infectious diseases in immunocompromised patients].Der nephrologe · 2016Article
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15 authors at 5 institutions in 3 countries.
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Abstract
backgroundThere have been numerous reports of clustered outbreaks of Pneumocystis pneumonia (PCP) at renal transplant centers over the past 2 decades. It has been unclear whether these outbreaks were linked epidemiologically to 1 or several unique strains, which could have implications for transmission patterns or strain virulence.
methodsRestriction fragment length polymorphism (RFLP) analysis was used to compare Pneumocystis isolates from 3 outbreaks of PCP in renal transplant patients in Germany, Switzerland, and Japan, as well as nontransplant isolates from both human immunodeficiency virus (HIV)-infected and uninfected patients.
resultsBased on RFLP analysis, a single Pneumocystis strain caused pneumonia in transplant patients in Switzerland (7 patients) and Germany (14 patients). This strain was different from the strain that caused an outbreak in transplant patients in Japan, as well as strains causing sporadic cases of PCP in nontransplant patients with or without HIV infection.
conclusionsTwo geographically distinct clusters of PCP in Europe were due to a single strain of Pneumocystis. This suggests either enhanced virulence of this strain in transplant patients or a common, but unidentified, source of transmission. Outbreaks of PCP can be better understood by enhanced knowledge of transmission patterns and strain variation.
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