ArticleInfection and immunity2012
Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: clearance after immunization, susceptibility to primaquine, and contribution to blood-stage infection.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Long-Read Genome Assembly and Gene Model Annotations for the Rodent Malaria ParasitebioRxiv : the preprint server for biology · 2023Article
- Killing the competition: a theoretical framework for liver-stage malaria.Open biology · 2022Article
- Current status of experimental models for the study of malaria.Parasitology · 2022Review
- Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development.Parasite immunology · 2021Review
- Safety and Efficacy of Tafenoquine forTherapeutics and clinical risk management · 2021Article
- Cryptic Plasmodium chronic infections: was Maurizio Ascoli right?Malaria journal · 2020Review
- Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice.Cell host & microbe · 2018Article
- Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity.Frontiers in immunology · 2018Review
- Progress in imaging methods: insights gained into Plasmodium biology.Nature reviews. Microbiology · 2017Review
- Clinical implications of a gradual dormancy concept in malaria.Parasitology research · 2016Review
- Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites.Journal of visualized experiments : JoVE · 2016Article
- Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes.Current opinion in microbiology · 2015Review
- From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.Seminars in immunopathology · 2015Review
- Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.PLoS pathogens · 2015Article
- Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections.Cellular microbiology · 2014Review
- Smuggling across the border: how arthropod-borne pathogens evade and exploit the host defense system of the skin.The Journal of investigative dermatology · 2014Review
- Using lymph node transplantation as an approach to image cellular interactions between the skin and draining lymph nodes during parasitic infections.Parasitology international · 2014Review
- Immune evasion strategies of pre-erythrocytic malaria parasites.Mediators of inflammation · 2014Review
- Looking under the skin: the first steps in malarial infection and immunity.Nature reviews. Microbiology · 2013Review
- CD8Current immunology reviews · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Plasmodium sporozoites are inoculated into the skin of the mammalian host as infected mosquitoes probe for blood. A proportion of the inoculum enters the bloodstream and goes to the liver, where the sporozoites invade hepatocytes and develop into the next life cycle stage, the exoerythrocytic, or liver, stage. Here, we show that a small fraction of the inoculum remains in the skin and begins to develop into exoerythrocytic forms that can persist for days. Skin exoerythrocytic forms were observed for both Plasmodium berghei and Plasmodium yoelii, two different rodent malaria parasites, suggesting that development in the skin of the mammalian host may be a common property of plasmodia. Our studies demonstrate that skin exoerythrocytic stages are susceptible to destruction in immunized mice, suggesting that their aberrant location does not protect them from the host's adaptive immune response. However, in contrast to their hepatic counterparts, they are not susceptible to primaquine. We took advantage of their resistance to primaquine to test whether they could initiate a blood-stage infection directly from the inoculation site, and our data indicate that these stages are not able to initiate malaria infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.