ArticleProceedings of the National Academy of Sciences of the United States of America2012
Pantropic retroviruses as a transduction tool for sea urchin embryos.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Snail 3G: genomics, genetics, and gene-editing ofFrontiers in genetics · 2026Review
- A method for microinjection of Patiria miniata zygotes.Journal of visualized experiments : JoVE · 2014Article
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Authors and funding
4 authors.
Funding
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Abstract
Sea urchins are an important model for experiments at the intersection of development and systems biology, and technical innovations that enhance the utility of this model are of great value. This study explores pantropic retroviruses as a transduction tool for sea urchin embryos, and demonstrates that pantropic retroviruses infect sea urchin embryos with high efficiency and genomically integrate at a copy number of one per cell. We successfully used a self-inactivation strategy to both insert a sea urchin-specific enhancer and disrupt the endogenous viral enhancer. The resulting self-inactivating viruses drive global and persistent gene expression, consistent with genomic integration during the first cell cycle. Together, these data provide substantial proof of principle for transduction technology in sea urchin embryos.
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