Trial reportHypertension (Dallas, Tex. : 1979)2012
Blood pressure response to controlled diesel exhaust exposure in human subjects.
Trial report in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Non-respiratory health risks and mortality associated with fighting bushfires (wildfires): a systematic review.International archives of occupational and environmental health · 2025Pooled it
- Systematic review of the effects of black carbon on cardiovascular disease among individuals with pre-existing disease.International journal of public health · 2013Pooled it
- Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration.Annals of internal medicine · 2023Trial
- Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.Environmental research · 2020Trial
- Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation.American journal of respiratory and critical care medicine · 2016Trial
- Association of Carbon Monoxide exposure with blood pressure among pregnant women in rural Ghana: Evidence from GRAPHS.International journal of hygiene and environmental health · 2016Trial
- A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans.Particle and fibre toxicology · 2013Trial
- Short-term effects of haze exposure on clinical and subclinical cardiovascular indicators among adults in Nanjing.Scientific reports · 2026Article
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.Environment international · 2025Article
- Exposure to Air Pollution and Changes in Resting Blood Pressure from Morning to Evening: The MobiliSense Study.International journal of environmental research and public health · 2025Article
- An analysis of trends in the burden of ischemic stroke caused by air pollution in China between 1990 and 2021.BMC public health · 2025Article
- Environmental Hypertensionology and the Mosaic Theory of Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Human exposure to aerosol from indoor gas stove cooking and the resulting cardiovascular system responses.Toxicology reports · 2024Article
- Exploring the impact of occupational exposure: A study on cardiovascular autonomic functions of male gas station attendants in Sri Lanka.Physiological reports · 2024Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- A Single Bout of Prolonged Sitting Augments Very Short-Term Blood Pressure Variability.American journal of hypertension · 2024Article
- Effects of long-term indoor air purification intervention on cardiovascular health in elderly: a parallel, double-blinded randomized controlled trial in Hong Kong.Environmental research · 2024Article
- Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to traffic-related air pollution is associated with risk of cardiovascular disease and mortality. We examined whether exposure to diesel exhaust increased blood pressure (BP) in human subjects. We analyzed data from 45 nonsmoking subjects, 18 to 49 years of age in double-blinded, crossover exposure studies, randomized to order. Each subject was exposed to diesel exhaust, maintained at 200 μg/m(3) of fine particulate matter, and filtered air for 120 minutes on days separated by ≥2 weeks. We measured BP pre-exposure, at 30-minute intervals during exposure, and 3, 5, 7, and 24 hours from exposure initiation and analyzed changes from pre-exposure values. Compared with filtered air, systolic BP increased at all of the points measured during and after diesel exhaust exposure; the mean effect peaked between 30 and 60 minutes after exposure initiation (3.8 mm Hg [95% CI: -0.4 to 8.0 mm Hg] and 5.1 mm Hg [95% CI: 0.7-9.5 mm Hg], respectively). Sex and metabolic syndrome did not modify this effect. Combining readings between 30 and 90 minutes, diesel exhaust exposure resulted in a 4.4-mm Hg increase in systolic BP, adjusted for participant characteristics and exposure perception (95% CI: 1.1-7.7 mm Hg; P=0.0009). There was no significant effect on heart rate or diastolic pressure. Diesel exhaust inhalation was associated with a rapid, measurable increase in systolic but not diastolic BP in young nonsmokers, independent of perception of exposure. This controlled trial in humans confirms findings from observational studies. The effect may be important on a population basis given the worldwide prevalence of exposure to traffic-related air pollution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.