ArticleMolecular and cellular biology2012
An RNA-independent linkage of noncoding transcription to long-range enhancer function.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures.Trends in genetics : TIG · 2022Review
- Splicing of enhancer-associated lincRNAs contributes to enhancer activity.Life science alliance · 2020Article
- Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.Molecular and cellular biology · 2018Article
- Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers.Genome biology · 2017Article
- A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.Nucleic acids research · 2017Article
- Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.Human molecular genetics · 2016Article
- High Fractional Occupancy of a Tandem Maf Recognition Element and Its Role in Long-Range β-Globin Gene Regulation.Molecular and cellular biology · 2016Article
- Review
- Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci.RNA (New York, N.Y.) · 2015Article
- Autonomous actions of the human growth hormone long-range enhancer.Nucleic acids research · 2015Article
- Genetics of RA susceptibility, what comes next?RMD open · 2015Review
- Article
- Uncovering enhancer functions using the α-globin locus.PLoS genetics · 2014Review
- Transcriptional regulatory functions of nuclear long noncoding RNAs.Trends in genetics : TIG · 2014Review
- Long noncoding RNAs as metazoan developmental regulators.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Identification of a secondary promoter within the human B cell receptor component gene hCD79b.The Journal of biological chemistry · 2013Article
- Mutations within lncRNAs are effectively selected against in fruitfly but not in human.Genome biology · 2013Article
- Identification of biologically relevant enhancers in human erythroid cells.The Journal of biological chemistry · 2013Article
- Recruitment of transcription complexes to enhancers and the role of enhancer transcription.Biology · 2012Article
- Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The detection of noncoding transcription at multiple enhancers within the mammalian genome raises critical questions regarding whether and how this activity contributes to enhancer function. Here, using in vivo analysis of a human growth hormone (hGH) transgene locus, we report that activation of a domain of noncoding transcription adjacent to the long-range hGH-N enhancer, HSI, is established by the enhancer independent of any interactions with its target promoter. We further demonstrate that the appearance of this enhancer-linked noncoding transcription is temporally and spatially concordant with induction of hGH-N in the embryonic pituitary. Finally, we show that the level of transcriptional enhancement of hGH-N by HSI is directly related to the intensity of HSI-dependent noncoding transcription and is fully independent of the structure of the locally transcribed RNA. These data extend our understanding of the relationship of long-range enhancer activity to enhancer-dependent noncoding transcription and establish a model that may be of general relevance to additional mammalian loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.