ArticleGenes & development2012
RNAi keeps Atf1-bound stress response genes in check at nuclear pores.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- A Temperature Increase Induces Atf1/Pcr1-Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin.bioRxiv : the preprint server for biology · 2025Article
- Chromodomain mutation in S. pombe Kat5/Mst1 affects centromere dynamics and DNA repair.PloS one · 2024Article
- Genetic Insight into the Domain Structure and Functions of Dicer-Type Ribonucleases.International journal of molecular sciences · 2021Review
- Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast.Cells · 2020Review
- Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway.Genetics · 2019Article
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
- Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability.Current genetics · 2019Review
- Article
- Daughter-cell-specific modulation of nuclear pore complexes controls cell cycle entry during asymmetric division.Nature cell biology · 2018Article
- Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage.The Journal of cell biology · 2017Article
- Transcriptional reprogramming in cellular quiescence.RNA biology · 2017Review
- RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.Nature structural & molecular biology · 2017Article
- Two sets of RNAi components are required for heterochromatin formation in trans triggered by truncated transgenes.Nucleic acids research · 2016Article
- Small RNAs: essential regulators of gene expression and defenses against environmental stresses in plants.Wiley interdisciplinary reviews. RNA · 2016Review
- A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.Cell · 2016Article
- H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.The EMBO journal · 2015Article
- Swiss army knives: non-canonical functions of nuclear Drosha and Dicer.Nature reviews. Molecular cell biology · 2015Review
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex.Nature structural & molecular biology · 2015Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNAi pathways are prevalent throughout the eukaryotic kingdom and are well known to regulate gene expression on a post-transcriptional level in the cytoplasm. Less is known about possible functions of RNAi in the nucleus. In the fission yeast Schizosaccharomyces pombe, RNAi is crucial to establish and maintain centromeric heterochromatin and functions to repress genome activity by a chromatin silencing mechanism referred to as cotranscriptional gene silencing (CTGS). Mechanistic details and the physiological relevance of CTGS are unknown. Here we show that RNAi components interact with chromatin at nuclear pores to keep stress response genes in check. We demonstrate that RNAi-mediated CTGS represses stress-inducible genes by degrading mRNAs under noninduced conditions. Under chronic heat stress conditions, a Dicer thermoswitch deports Dicer to the cytoplasm, thereby disrupting CTGS and enabling expression of genes implicated in the acquisition of thermotolerance. Taken together, our work highlights a role for nuclear pores and the stress response transcription factor Atf1 in coordinating the interplay between the RNAi machinery and the S. pombe genome and uncovers a novel mode of RNAi regulation in response to an environmental cue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.