ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of exposure to ethinyl estradiol during pregnancy and lactation on the postinvolution mammary gland.Journal of the Endocrine Society · 2026Article
- The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling.International journal of biological sciences · 2026Review
- Mast Cells Are Not Essential for Pubertal Mammary Gland Branching.European journal of immunology · 2025Article
- An ovine model for investigation of the microenvironment of the male mammary gland.Journal of anatomy · 2024Article
- Immune Cell Contribution to Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2024Review
- The immune environment of the mammary gland fluctuates during post-lactational regression and correlates with tumour growth rate.Development (Cambridge, England) · 2022Article
- The Cellular Organization of the Mammary Gland: Insights From Microscopy.Journal of mammary gland biology and neoplasia · 2021Review
- Macphatics and PoEMs in Postpartum Mammary Development and Tumor Progression.Journal of mammary gland biology and neoplasia · 2020Review
- Dynamic architectural interplay between leucocytes and mammary epithelial cells.The FEBS journal · 2020Article
- A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types.Animals : an open access journal from MDPI · 2019Article
- Studies of postpartum mammary gland involution reveal novel pro-metastatic mechanisms.Journal of cancer metastasis and treatment · 2019Article
- Semaphorin 7A Promotes Macrophage-Mediated Lymphatic Remodeling during Postpartum Mammary Gland Involution and in Breast Cancer.Cancer research · 2018Article
- Mucosal Immunity in the Female Murine Mammary Gland.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer.International journal of molecular sciences · 2018Review
- The Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents: A One Health Focus.Journal of mammary gland biology and neoplasia · 2018Review
- Deciphering Pro-Lymphangiogenic Programs during Mammary Involution and Postpartum Breast Cancer.Frontiers in oncology · 2016Review
- Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis.Cancer cell & microenvironment · 2015Article
- Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer.The Journal of clinical investigation · 2014Article
- Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.Journal of mammary gland biology and neoplasia · 2014Review
- Immune cell quantitation in normal breast tissue lobules with and without lobulitis.Breast cancer research and treatment · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe mammary epithelium undergoes proliferation and regression accompanied by remodeling of the fibrocellular and vascular stroma. Mast cells are abundant in these compartments and have been implicated in remodeling during wound healing and cancer progression. The purpose of this study was to test the hypothesis that mast cell abundance correlates with physiologic mammary tissue remodeling during estrous cycling, lactogenesis (pregnancy and lactation) and involution.
resultsMast cell and capillary frequency were quantified in the stroma surrounding ducts and lobules from mammary glands of rats. During estrous cycling, periductal mast cell numbers were unchanged, but lobule-associated mast cells significantly increased in the regressive phase of diestrus II. During lactogenesis, lobular stroma mast cells peaked early in pregnancy, at D2, followed by a significant decrease throughout lactation. Involution was associated with a rapid return in mast cell numbers, similar to diestrus II. Lobular vascularization peaked during the state of metestrus, when limited secretory differentiation occurs. Lobular angiogenesis peaked at D7 of pregnancy, regressed, and then returned to high levels during lactation and early involution, when secretory differentiation is high.
conclusionsThese results suggest mast cells are predominantly associated with regressive lobular remodeling during cycling and involution, whereas angiogenesis is predominantly associated with secretory differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.