Evidence map›Paper›PMID 22431222›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2012

Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.

James A Madsen, Ryan R Cheng, Tamer S Kaoud, Kevin N Dalby, Dmitrii E Makarov, Jennifer S Brodbelt

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Peptide Analysis by Soft X-ray Atmospheric Pressure Photoionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. TRPM7.Handbook of experimental pharmacology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James A MadsenDepartment of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, TX 78712, USA.
Ryan R Cheng
Tamer S Kaoud
Kevin N Dalby
Dmitrii E Makarov
Jennifer S Brodbelt

Funding

Mechanism and Specificity of MAP KinasesR01GM059802 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI DALBY, KEVIN N · 2001 to 2011
$2.3M
NIGMS NIH HHS GM 59802NIGMS NIH HHS R01 GM059802
6 · The paper itself

Abstract

Here, 193 nm vacuum ultraviolet photodissociation (VUVPD) was used to investigate the fragmentation of hydrogen-rich radical peptide cations generated by electron transfer reactions. VUVPD offers new insight into the factors that drive radical- and photon-directed processes. The location of a basic Arg site influences photon-activated C(α)-C(O) bond cleavages of singly charged peptide radical cations, an outcome attributed to the initial conformation of the peptide as supported by molecular dynamics simulated annealing and the population of excited states upon UV excitation. This hybrid ETD/VUVPD method was employed to identify phosphorylation sites of the kinase domain of human TRPM7/ChaK1.

Indexed as

Amino Acid SequenceCationsElectronsFree RadicalsHumansHydrogenMass SpectrometryPeptidesPhosphorylationProtein Serine-Threonine KinasesSpectrophotometry, UltravioletTRPM Cation ChannelsCationsFree RadicalsHydrogenPeptidesProtein Serine-Threonine KinasesTRPM7 protein, humanTRPM Cation Channels

Identifiers

PMID22431222
PMCPMC4136645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.