ArticleThe Journal of comparative neurology2012
Characterization of cell proliferation throughout the brain of the African cichlid fish Astatotilapia burtoni and its regulation by social status.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 80 citations in OpenAlex.
- Ultrastructural Characteristics of the Juvenile Chum Salmon (International journal of molecular sciences · 2025Article
- Larger Fish Have Larger Brains With More Neurons Across but Not Within Cohorts Raised in Different Growth Conditions.The Journal of comparative neurology · 2025Article
- Ultrastructural Study and Immunohistochemical Characteristics of Mesencephalic Tegmentum in Juvenile Chum Salmon (International journal of molecular sciences · 2025Article
- Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids.Annals of the New York Academy of Sciences · 2024Article
- Oxidative stress in the brain is regulated by social status in a highly social cichlid fish.Frontiers in behavioral neuroscience · 2024Article
- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- Cellular profiling of a recently-evolved social behavior in cichlid fishes.Nature communications · 2023Article
- Article
- Molecular Markers of Adult Neurogenesis in the Telencephalon and Tectum of Rainbow Trout,International journal of molecular sciences · 2022Article
- Article
- Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators.Frontiers in cell and developmental biology · 2022Review
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Neural and endocrine responses to social stress differ during actual and virtual aggressive interactions or physiological sign stimuli.Behavioural processes · 2021Article
- Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease.Frontiers in cell and developmental biology · 2020Review
- Genome-wide effects of social status on DNA methylation in the brain of a cichlid fish, Astatotilapia burtoni.BMC genomics · 2019Article
- Validation of hippocampal biomarkers of cumulative affective experience.Neuroscience and biobehavioral reviews · 2019Review
- Male dominance status regulates odor-evoked processing in the forebrain of a cichlid fish.Scientific reports · 2019Article
- Review
- The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan.BMC developmental biology · 2018Article
- Solving the Neurogenesis Puzzle: Looking for Pieces Outside the Traditional Box.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
New cells are added in the brains of all adult vertebrates, but fishes have some of the greatest potential for neurogenesis and gliogenesis among all taxa, partly due to their indeterminate growth. Little is known, however, about how social interactions influence cell proliferation in the brain of these fishes that comprise the largest group of vertebrates. We used 5-bromo-2'-deoxyuridine (BrdU) to identify and localize proliferation zones in the telencephalon, diencephalon, mesencephalon, and rhombencephalon that were primarily associated with ventricular surfaces in the brain of the African cichlid fish Astatotilapia burtoni. Cell migration was evident in some regions by 1 day post injection, and many newborn cells coexpressed the neuronal marker HuC/D at 30 days, suggesting they had differentiated into neurons. To test the hypothesis that social status and perception of an opportunity to rise in rank influenced cell proliferation, we compared numbers of BrdU-labeled cells in multiple brain nuclei among fish of different social status. Socially suppressed subordinate males had the lowest numbers of proliferating cells in all brain regions examined, but males that were given an opportunity to rise in status had higher cell proliferation rates within 1 day, suggesting rapid upregulation of brain mitotic activity associated with this social transition. Furthermore, socially isolated dominant males had similar numbers of BrdU-labeled cells compared with dominant males that were housed in a socially rich environment, suggesting that isolation has little effect on proliferation and that reduced proliferation in subordinates is a result of the social subordination. These results suggest that A. burtoni will be a useful model to analyze the mechanisms of socially induced neurogenesis in vertebrates.
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Registered trials
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