Evidence map›Paper›PMID 22431145›Full record

Trial reportClinical oral investigations2013

One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial.

Saeed Asgary, Mohammad Jafar Eghbal, Jamileh Ghoddusi, Shahram Yazdani

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03410134 (Clinical Evaluation of Vital Pulp Therapy in Young Permanent Molars With Irreversible Pulpitis), which is not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03410134 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Clinical Evaluation of Vital Pulp Therapy in Young Permanent Molars With Irreversible Pulpitis

TypeinterventionalSponsorHacettepe UniversityRan2017 to 2023Enrolled300ConditionsDental Caries Extending to Pulp, Pulp Disease, DentalArmsNeoMTA
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  10. Mineral Trioxide AggregateIranian endodontic journal · 2022
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  12. Two-year outcomes of electrosurgery and calcium-enriched mixture pulpotomy in primary teeth: a randomised clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2014
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Saeed AsgaryIranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Evin, 1983963113 Tehran, Iran. saasgary@yahoo.com
Mohammad Jafar Eghbal
Jamileh Ghoddusi
Shahram Yazdani
Shahid Beheshti University of Medical Sciences · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRoot canal therapy (RCT) and tooth extraction have been conventional treatment options for management of human mature teeth with irreversible pulpitis. Excellent short-term treatment outcomes of vital pulp therapy with calcium-enriched mixture cement (VPT/CEM), as a new treatment option, on postoperative pain relief was demonstrated; if intermediate- and long-term treatment outcomes of the new treatment are also non-inferior compared to RCT, then VPT/CEM may become a viable treatment option for management of mature teeth with irreversible pulpitis. MATERIALS AND

methodsIn 23 healthcare centers, 407 9- to 65-year-old patients were randomly allocated into two study arms including one-visit RCT (reference treatment; n = 202) and VPT/CEM (alternative treatment; n = 205). Six- and twelve-month clinical and radiographic successes were assessed.

resultsMean follow-up times at 6- and 12-month follow-ups were "6.70 ± 0.68 and 6.72 ± 0.71 months" and "12.96 ± 0.67 and 12.90 ± 0.66 months" in the available cases of RCT and VPT/CEM arms, respectively. Favorable clinical success rates in the two study arms did not show statistical difference; however, the radiographic success rate in the VPT/CEM was significantly greater than RCT arm at the two follow-ups (P < 0.001). The patients' age had no effect on the treatment outcomes (P = 0.231).

conclusionsTreatment outcomes of VPT/CEM may be superior to RCT in mature molars with irreversible pulpitis. The performance of biomaterials such CEM cement may assist in the shift towards more biologic treatments. CLINICAL RELEVANCE: VPT/CEM may be a realistic alternative treatment for human mature molar teeth with symptoms of irreversible pulpitis; the use of VPT/CEM is highly beneficial for patients as well as general dentists.

Indexed as

AdolescentAdultAgedCalcium CompoundsChildEpoxy ResinsFemaleFollow-Up StudiesGutta-PerchaHumansMaleMiddle AgedMolarPeriapical TissuePulp Capping and Pulpectomy AgentsPulpitisCalcium Compoundsepoxy resin-based root canal sealerEpoxy ResinsGutta-PerchaPulp Capping and Pulpectomy AgentsRoot Canal Filling Materials

Identifiers

PMID22431145
OpenAlexW2004871995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.