ArticleLipids2012
Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological study.
Article in Lipids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Omega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebo-controlled trial.BMC pregnancy and childbirth · 2017Trial
- Prenatal n-3 long-chain fatty acid status and offspring metabolic health in early and mid-childhood: results from Project Viva.Nutrition & diabetes · 2018Article
- Article
- Early pregnancy body mass index modifies the association of pre-pregnancy dietary patterns with serum polyunsaturated fatty acid concentrations throughout pregnancy in Brazilian women.Maternal & child nutrition · 2018Article
- Serum n-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy.Epidemiology and psychiatric sciences · 2017Article
- Methyl mercury, but not inorganic mercury, associated with higher blood pressure during pregnancy.Environmental research · 2017Article
- An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells.Journal of lipid research · 2017Article
- Differences in long chain polyunsaturates composition and metabolism in male and female rats.Prostaglandins, leukotrienes, and essential fatty acids · 2016Article
- Cord Blood Methylmercury and Fetal Growth Outcomes in Baltimore Newborns: Potential Confounding and Effect Modification by Omega-3 Fatty Acids, Selenium, and Sex.Environmental health perspectives · 2016Article
- Article
- Association of selenium and copper with lipids in umbilical cord blood.Journal of developmental origins of health and disease · 2014Article
- Article
- Mass spectrometry methodology in lipid analysis.International journal of molecular sciences · 2014Review
- Omega-6 fatty acids and greater likelihood of suicide risk and major depression in early pregnancy.Journal of affective disorders · 2014Article
- Development and validation of a robust automated analysis of plasma phospholipid fatty acids for metabolic phenotyping of large epidemiological studies.Genome medicine · 2013Article
- Article
- Maternal prenatal fish consumption and cognition in mid childhood: Mercury, fatty acids, and selenium.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Large population studies show that polyunsaturated fatty acids are important for human health, but determining relationships between the health benefits and the fatty acid content has been hampered by the unavailability of labor-effective high-throughput technologies. An automated high throughput fatty acid analysis was developed from a previous procedure based on direct transesterification including the automation of chemical procedures, data acquisition and automatic data processing. The method was validated and applied to umbilical cord serum samples in an epidemiological study. The method was linear in the range of 1-600 μg/mL serum with r² ≥ 0.99. The within-run CV was <5.4% for 23 fatty acids and a range of recoveries over three concentrations were 76-119% in a low-lipid matrix with the exception of 14:0. The fatty acid concentration as measured by the robotic method for human plasma was in good agreement with the Lepage & Roy method. The fatty acid profile in umbilical cord serum from American subjects (n = 287) showed an average of 38.0, 24.9, 32.0 and 4.6% of total fatty acids for saturates, monounsaturates, n-6 and n-3 polyunsaturates, respectively. This is the first report of a complete, validated, cost-effective, automated, high throughput fatty acid measurement method along with application to a population-based study. Automated fatty acid analysis coupled with automated data processing greatly facilitates the high throughput, 72 samples transesterified in 6 h, required for large population-based studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.