ArticleEpigenetics2012
DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Epidemiological Trends in Gastrointestinal Cancers in China: An Ecological Study.Digestive diseases and sciences · 2019Article
- Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers.Oncotarget · 2017Article
- Comparison of Blueberry (Journal of cancer prevention · 2017Article
- Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia.Oncology letters · 2017Article
- Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors.Clinical epigenetics · 2017Review
- Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.International journal of molecular sciences · 2016Article
- Quantification of gene-specific methylation of DNMT3B and MTHFR using sequenom EpiTYPER®.Data in brief · 2016Article
- Article
- Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.Epigenetics · 2014Article
- The functional role of long non-coding RNAs and epigenetics.Biological procedures online · 2014Review
- Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans.Human genetics · 2013Article
- Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India.PloS one · 2013Article
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancers of the upper aerodigestive tract (UADT) are common forms of malignancy associated with tobacco and alcohol exposures, although human papillomavirus and nutritional deficiency are also important risk factors. While somatically acquired DNA methylation changes have been associated with UADT cancers, what triggers these events and precise epigenetic targets are poorly understood. In this study, we applied quantitative profiling of DNA methylation states in a panel of cancer-associated genes to a case-control study of UADT cancers. Our analyses revealed a high frequency of aberrant hypermethylation of several genes, including MYOD1, CHRNA3 and MTHFR in UADT tumors, whereas CDKN2A was moderately hypermethylated. Among differentially methylated genes, we identified a new gene (the nicotinic acetycholine receptor gene) as target of aberrant hypermethylation in UADT cancers, suggesting that epigenetic deregulation of nicotinic acetycholine receptors in non-neuronal tissues may promote the development of UADT cancers. Importantly, we found that sex and age is strongly associated with the methylation states, whereas tobacco smoking and alcohol intake may also influence the methylation levels in specific genes. This study identifies aberrant DNA methylation patterns in UADT cancers and suggests a potential mechanism by which environmental factors may deregulate key cellular genes involved in tumor suppression and contribute to UADT cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.