ArticleEpigenetics2012
Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies.BMC pulmonary medicine · 2017Pooled it
- The impact of exercise on gene regulation in association with complex trait genetics.Nature communications · 2024Article
- TESTING FOR THE CAUSAL MEDIATION EFFECTS OF MULTIPLE MEDIATORS USING THE KERNEL MACHINE DIFFERENCE METHOD IN GENOME-WIDE EPIGENETIC STUDIES.The annals of applied statistics · 2024Article
- Cohort Network: A Knowledge Graph toward Data Dissemination and Knowledge-Driven Discovery for Cohort Studies.Environmental science & technology · 2023Article
- Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies.Journal of the American Statistical Association · 2022Article
- Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients.Disease markers · 2022Article
- How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?International journal of molecular sciences · 2021Review
- FUNCTION-ON-FUNCTION REGRESSION FOR THE IDENTIFICATION OF EPIGENETIC REGIONS EXHIBITING WINDOWS OF SUSCEPTIBILITY TO ENVIRONMENTAL EXPOSURES.The annals of applied statistics · 2021Article
- Sex-specific longitudinal association of DNA methylation with lung function.ERJ open research · 2021Article
- Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer.Journal of the National Cancer Institute · 2021Article
- Epigenome-scale comparison of DNA methylation between blood leukocytes and bronchial epithelial cells.Epigenomics · 2021Article
- Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood.Clinical epigenetics · 2021Article
- Long-Term Disturbed Expression and DNA Methylation of SCAP/SREBP Signaling in the Mouse Lung From Assisted Reproductive Technologies.Frontiers in genetics · 2021Article
- Article
- Changes of DNA methylation are associated with changes in lung function during adolescence.Respiratory research · 2020Article
- Chromatin Architecture as an Essential Determinant of Dendritic Cell Function.Frontiers in immunology · 2019Review
- Gene Promoter Hypermethylation Detected in Sputum Predicts FEVAmerican journal of respiratory and critical care medicine · 2018Article
- Abnormal Epigenetic Regulation of Immune System during Aging.Frontiers in immunology · 2018Review
- Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model.Journal of Alzheimer's disease : JAD · 2018Review
- Association betweenEpigenetics · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Lung function is a strong predictor of mortality. While inflammatory markers have been associated with lung function decrease, pathways are still poorly understood and epigenetic changes may participate in lung function decline mechanisms. We studied the cross-sectional association between DNA methylation in nine inflammatory genes and lung function in a cohort of 756 elderly men living in the metropolitan area of Boston. Participants donated a blood sample for DNA methylation analysis and underwent spirometry at each visit every 3 to 5 y from 1999-2006. We used separate multivariate mixed effects regression models to study the association between each lung function measurement and DNA methylation within each gene. Decreased CRAT, F3 and TLR2 methylation was significantly associated with lower lung function. One interquartile range (IQR) decrease in DNA methylation was associated with lower forced vital capacity (FVC) and forced expiratory volume in one second (FEV 1), respectively by 2.94% (p < 10 (-4)) and 2.47% (p < 10 (-3)) for F3, and by 2.10% (p < 10 (-2)) and 2.42% (p < 10 (-3)) for TLR2. Decreased IFNγ and IL6 methylation was significantly associated with better lung function. One IQR decrease in DNA methylation was associated with higher FEV 1 by 1.75% (p = 0.02) and 1.67% (p = 0.05) for IFNγ and IL6, respectively. These data demonstrate that DNA methylation may be part of the biological processes underlying the lung function decline and that IFNγ and IL6 may have ambivalent roles through activation of negative feedback.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.