ArticleMicrobial ecology2012
Culturable endophytes of medicinal plants and the genetic basis for their bioactivity.
Article in Microbial ecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- The phyllosphere of Nigerian medicinal plants, Euphorbia lateriflora and Ficus thonningii is inhabited by a specific microbiota.Scientific reports · 2024Article
- Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth.Plant cell reports · 2024Article
- Endophytic bacteria: a sustainable strategy for enhancing medicinal plant cultivation and preserving microbial diversity.Frontiers in microbiology · 2024Review
- Diversity analysis of endophytes with antimicrobial and antioxidant potential from Viola odorata: an endemic plant species of the Himalayas.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Insights into the Methodological, Biotic and Abiotic Factors Influencing the Characterization of Xylem-Inhabiting Microbial Communities of Olive Trees.Plants (Basel, Switzerland) · 2023Review
- Article
- Prospecting potential of endophytes for modulation of biosynthesis of therapeutic bioactive secondary metabolites and plant growth promotion of medicinal and aromatic plants.Antonie van Leeuwenhoek · 2022Review
- In Vitro Antitumor Activity of Endophytic and Rhizosphere Gram-Positive Bacteria fromInternational journal of environmental research and public health · 2022Article
- The cypsela (achene) of Echinacea purpurea as a diffusion unit of a community of microorganisms.Applied microbiology and biotechnology · 2021Article
- Plant Growth-Promoting Endophytic Bacterial Community Inhabiting the Leaves ofPlants (Basel, Switzerland) · 2021Article
- Culturable diversity of bacterial endophytes associated with medicinal plants of the Western Ghats, India.FEMS microbiology ecology · 2020Article
- Genome mining of a fungal endophyte of Taxus yunnanensis (Chinese yew) leads to the discovery of a novel azaphilone polyketide, lijiquinone.Microbial biotechnology · 2020Article
- Multiple Plant Growth-Promotion Traits in Endophytic Bacteria Retrieved in the Vegetative Stage From Passionflower.Frontiers in plant science · 2020Article
- The Cultivable Bacterial Microbiota Associated to the Medicinal PlantFrontiers in microbiology · 2020Article
- Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds.Folia microbiologica · 2018Article
- Effects of an Endophytic FungusFrontiers in microbiology · 2018Article
- Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches.Frontiers in microbiology · 2018Review
- Plant growth-promoting activities for bacterial and fungal endophytes isolated from medicinal plant ofJournal of advanced research · 2017Article
- Article
- Lasiodiplodia sp. ME4-2, an endophytic fungus from the floral parts of Viscum coloratum, produces indole-3-carboxylic acid and other aromatic metabolites.BMC microbiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bioactive compounds of medicinal plants are products of the plant itself or of endophytes living inside the plant. Endophytes isolated from eight different anticancer plants collected in Yunnan, China, were characterized by diverse 16S and 18S rRNA gene phylogenies. A functional gene-based molecular screening strategy was used to target nonribosomal peptide synthetase (NRPS) and type I polyketide synthase (PKS) genes in endophytes. Bioinformatic analysis of these biosynthetic pathways facilitated inference of the potential bioactivity of endophyte natural products, suggesting that the isolated endophytes are capable of producing a plethora of secondary metabolites. All of the endophyte culture broth extracts demonstrated antiproliferative effects in at least one test assay, either cytotoxic, antibacterial or antifungal. From the perspective of natural product discovery, this study confirms the potential for endophytes from medicinal plants to produce anticancer, antibacterial and antifungal compounds. In addition, PKS and NRPS gene screening is a valuable method for screening isolates of biosynthetic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.