ArticleMicrobial ecology2012
Structural shifts of fecal microbial communities in rats with acute rejection after liver transplantation.
Article in Microbial ecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02223468 (Prospective Study To Characterize The Human Microbiota In Liver Transplantation And Its Impact On Early Outcome), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study To Characterize The Human Microbiota In Liver Transplantation And Its Impact On Early Outcome
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Cognitive Impairment in Liver Transplant Recipients With a History of Cirrhosis: A Systematic Review.Transplantation direct · 2023Article
- Biliary Diseases from the Microbiome Perspective: How Microorganisms Could Change the Approach to Benign and Malignant Diseases.Microorganisms · 2022Review
- The role of bacterial translocation in sepsis: a new target for therapy.Therapeutic advances in gastroenterology · 2022Review
- Dysbiosis and Depletion of Fecal Organic Acids Correlate With the Severity of Rejection After Rat Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Gut microbiota alterations associated with antibody-mediated rejection after kidney transplantation.Applied microbiology and biotechnology · 2021Article
- Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery.International journal of molecular sciences · 2020Review
- Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats.Annals of transplantation · 2020Article
- Focus on the Gut-Kidney Axis in Health and Disease.Frontiers in medicine · 2020Review
- Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?Diseases (Basel, Switzerland) · 2019Review
- Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic liver transplantation.Frontiers of medicine · 2019Article
- Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes.Transplantation · 2019Review
- Optimal immunosuppressor induces stable gut microbiota after liver transplantation.World journal of gastroenterology · 2018Article
- Gut microbial balance and liver transplantation: alteration, management, and prediction.Frontiers of medicine · 2018Review
- Characteristics of fecal microbial communities in patients with non-anastomotic biliary strictures after liver transplantation.World journal of gastroenterology · 2017Observational
- Impact of environmental factors on alloimmunity and transplant fate.The Journal of clinical investigation · 2017Review
- The digestive tract as the origin of systemic inflammation.Critical care (London, England) · 2016Review
- Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats.Journal of translational medicine · 2016Article
- Gut microbiota and allogeneic transplantation.Journal of translational medicine · 2015Review
- Effect of intestinal microbiota alteration on hepatic damage in rats with acute rejection after liver transplantation.Microbial ecology · 2014Article
- Intestinal microbial variation may predict early acute rejection after liver transplantation in rats.Transplantation · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial translocation and the development of sepsis after orthotopic liver transplantation (OLT) may be promoted by immunological damage to the intestinal mucosa or by quantitative and qualitative changes in intestinal microbiota. This study monitored structural shifts of gut microbiota in rats with OLT using PCR-denaturing gradient gel electrophoresis (DGGE) and real-time quantitative PCR (RT-qPCR). RT-qPCR targets six major microorganisms (Domain Bacteria, Bacteroides, Bifidobacteria, Enterobacteriaceae, Lactobacillus and Clostridium leptum subgroup). Isograft, Allograft and Sham model were studied. Bacterial translocation to host organs and plasma endotoxin were determined. Alteration in gut microbiota was associated with the elevation of plasma endotoxin and a higher rate of bacterial translocation (BT) to liver in rats with acute rejection. Dynamic analysis of DGGE fingerprints showed that the gut microbiota structure of animals in the three groups was similar before the operation. But significant alterations in the composition of fecal microbiota in Allograft group were observed at 1 and 2 weeks after the OLT. The acute rejection was accompanied by the shifts of gut microbiota towards members of Bacteroides and Ruminococcus. Results from RT-qPCR indicated that Bacteroides significantly increased at 2 weeks after the OLT, whereas numbers of Bifidobacterium spp. decreased at 1 week and recovered at 2 weeks after the OLT. In summary, our data showed that rats with acute rejection after OLT exhibited significant structure shifts in the gut microbiota which dominant by overgrowth of Bacteroides and Ruminococcus, and these were associated with elevation of plasma endotoxin and higher rate of BT.
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