Evidence map›Paper›PMID 22430146›Full record

ReviewCurrent heart failure reports2012

Role of physical training in heart failure with preserved ejection fraction.

Mark Haykowsky, Peter Brubaker, Dalane Kitzman

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current heart failure reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03111017 (Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients With Preserved Ejection Fraction), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03111017 nacompletednot on this mapstarted 2017, after this paper: background citation

Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients With Preserved Ejection Fraction

TypeinterventionalSponsorThe University of Texas at ArlingtonRan2017 to 2019Enrolled12ConditionsHeart Failure, DiastolicArmsExercise Training
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mark HaykowskyFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, T6G 2 G4, Canada. mark.haykowsky@ualberta.ca
Peter Brubaker
Dalane Kitzman
Wake Forest University · USUniversity of Alberta · CA

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
NIA NIH HHS P30 AG021332NIA NIH HHS P30AG21332NIA NIH HHS R01 AG018915NIA NIH HHS R37 AG018915NIA NIH HHS R37AG18915
6 · The paper itself

Abstract

About 50% or more of heart failure (HF) patients living in the community have preserved left ventricular ejection fraction (HFpEF), and the proportion is higher among women and the very elderly. A cardinal feature of HFpEF is reduced aerobic capacity, measured objectively as peak exercise pulmonary oxygen uptake (peak VO(2)), that results in decreased quality of life. Specifically, peak VO(2) of HFpEF patients is 30-70% lower than age-, sex-, and comorbidity-matched control patients without HF. The mechanisms for the reduced peak VO(2) are due to cardiovascular and skeletal muscle dysfunction that results in reduced oxygen delivery to and/or utilization by the active muscles. Currently, four randomized controlled exercise intervention trials have been performed in HFpEF patients. These studies have consistently demonstrated that 3-6 months of aerobic training performed alone or in combination with strength training is a safe and effective therapy to increase aerobic capacity and endurance and quality of life in HFpEF patients. Despite these benefits, the physiologic mechanisms underpinning the improvement in peak exercise performance have not been studied; therefore, future studies are required to determine the role of physical training to reverse the impaired cardiovascular and skeletal muscle function in HFpEF patients.

Indexed as

Exercise TherapyHeart FailureHumansOxygen ConsumptionRandomized Controlled Trials as TopicStroke Volume

Identifiers

PMID22430146
PMCPMC4415355
OpenAlexW2058551665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.