Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Effects of working memory training on depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.Translational psychiatry · 2026Pooled it
- A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Pooled it
- The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review.Journal of psychopharmacology (Oxford, England) · 2022Pooled it
- Vascular depression in Black Americans: A systematic review of the construct and its cognitive, functional, and psychosocial correlates.The Clinical neuropsychologist · 2022Pooled it
- The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Trial
- Accelerated Cognitive Decline in Late Life Depression: The Role of Amyloid-β, Cortico-Limbic Volume, and White Matter Hyperintensities.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies.Molecular psychiatry · 2025Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Depression and Pseudodementia: Decoding the Intricate Bonds in an Italian Outpatient Setting.Brain sciences · 2023Article
- Impact of cardiovascular risk factors on the relationships of physical activity with mood and cognitive function in a diverse sample.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2023Article
- Models of depressive pseudoamnestic disorder.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Be Fit, Be Sharp, Be Well: The Case for Exercise as a Treatment for Cognitive Impairment in Late-life Depression.Journal of the International Neuropsychological Society : JINS · 2021Review
- Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression.Neuropharmacology · 2021Article
- Cognitive variability, brain aging, and cognitive decline in late-life major depression.International journal of geriatric psychiatry · 2021Article
- Molecular imaging of beta-amyloid deposition in late-life depression.Neurobiology of aging · 2021Article
- The Role of Exercise in Management of Mental Health Disorders: An Integrative Review.Annual review of medicine · 2021Review
- Baseline predictors of cognitive change in the treatment of major depressive episode: systematic review.BJPsych open · 2020Article
- Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits.International psychogeriatrics · 2020Article
- Do Antidepressants Increase the Risk of Dementia?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- Exploratory Study of Executive Function Abilities Across the Adult Lifespan in Individuals Receiving an ASD Diagnosis in Adulthood.Journal of autism and developmental disorders · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression.
designMeasurement of cognition both before and following 12 weeks of treatment with sertraline.
settingUniversity medical centers (Washington University and Duke University).
participantsOne hundred sixty-six individuals with late-life depression.
interventionSertraline treatment. MEASUREMENTS: The cognitive tasks were grouped into five domains (language, processing speed, working memory, episodic memory, and executive function). We measured vascular risk using the Framingham Stroke Risk Profile measure. We measured T2-based white matter hyperintensities using the Fazekas criteria.
resultsBoth episodic memory and executive function demonstrated significant improvement among adults with late-life depression during treatment with sertraline. Importantly, older age, higher vascular risk scores, and lower baseline Mini-Mental State Examination scores predicted less change in working memory. Furthermore, older age, later age of onset, and higher vascular risk scores predicted less change in executive function.
conclusionsThese results have important clinical implications in that they suggest that a regular assessment of vascular risk in older adults with depression is necessary as a component of treatment planning and in predicting prognosis, both for the course of the depression itself and for the cognitive impairments that often accompany depression in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.