ArticleCancer genetics
Monoclonality of multifocal epithelioid hemangioendothelioma of the liver by analysis of WWTR1-CAMTA1 breakpoints.
Article in Cancer genetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- MRI findings for differentiating benign and malignant soft tissue tumors: a systematic review-part 2: key imaging findings.Skeletal radiology · 2026Pooled it
- Recurrence of Epithelioid Hemangioendothelioma during Pregnancy: Case Report and Systematic Review.The Permanente journal · 2016Pooled it
- CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases.Frontiers in oncology · 2025Article
- Hepatic epithelioid hemangioendothelioma withFrontiers in oncology · 2025Article
- The challenges of hepatic epithelioid hemangioendothelioma: the diagnosis and current treatments of a problematic tumor.Orphanet journal of rare diseases · 2024Review
- Article
- Updated information regarding management of hepatic epithelioid hemangioendothelioma.Intractable & rare diseases research · 2022Article
- The genetics of vascular tumours: an update.Histopathology · 2022Review
- Successful surgical treatment of epithelioid hemangioendothelioma involving multiple liver lesions and bilateral lung nodules.Respiratory medicine case reports · 2022Article
- Rare epithelioid hemangioendothelioma in the brachiocephalic vein for long-term survival after surgery: A case report.SAGE open medical case reports · 2022Article
- Article
- Epithelioid hemangioendothelioma of spine: A case report with review of literatures.Radiology case reports · 2020Article
- Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review.World journal of surgical oncology · 2020Review
- Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases.Diagnostic pathology · 2020Article
- Epithelioid hemangioendothelioma of the bone: A case report with findings of bone scintigraphy.Medicine · 2019Article
- Expanding the Spectrum of Genetic Alterations in Pseudomyogenic Hemangioendothelioma With Recurrent Novel ACTB-FOSB Gene Fusions.The American journal of surgical pathology · 2018Article
- Article
- Vascular tumours of the liver: a particular story.Translational gastroenterology and hepatology · 2018Review
- Hepatic epithelioid hemangioendothelioma with metastasis to the mesentery of the small intestine: A case report.Molecular and clinical oncology · 2017Article
- Suprasellar epithelioid hemangioendothelioma: Case report and review of the literature.Surgical neurology international · 2016Article
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5 authors.
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Abstract
Similar to other vascular tumors, epithelioid hemangioendothelioma (EHE) can have multifocal presentation in up to 50% of cases. However, whether multifocal EHE represents an unusual pattern of metastasis or multiple separate primary tumors remains to be elucidated. Our recent identification of a WWTR1-CAMTA1 fusion as the genetic hallmark of EHE irrespective of anatomic location was used to clarify this question by comparing the similarity of translocation breakpoints. In our previous study, we found variability of the fusion transcripts of the t(1;3)(p36;q25) translocation among different patients with EHE. Thus, we undertook a molecular analysis of six samples from two patients with multicentric hepatic EHE to test our hypothesis that the presence of identical breakpoints in WWTR1 and CAMTA1 support the monoclonal nature of multifocal EHE. Using reverse transcription-polymerase chain reaction (RT-PCR) and subsequent sequencing, we confirmed an identical WWTR1-CAMTA1 fusion transcript product from different nodules in each patient. Our results confirm that multifocal EHE are monoclonal and thus represent metastatic implants of the same neoplastic clone rather than a "field-effect" or synchronous occurrence of multiple neoplastic clones.
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