ArticleMalaria journal2012
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Risk factors for inadequate and excessive gestational weight gain in 25 low- and middle-income countries: An individual-level participant meta-analysis.PLoS medicine · 2023Pooled it
- Serum lipids and lipoproteins in malaria--a systematic review and meta-analysis.Malaria journal · 2013Pooled it
- Incidence of malaria-related fever and morbidity due to Plasmodium falciparum among HIV1-infected pregnant women: a prospective cohort study in South Benin.Malaria journal · 2014Trial
- Epidemiology of malaria in pregnant women attending antenatal consultation in Dschang, West Cameroon.Journal of public health in Africa · 2025Article
- Association between peripheral markers in women with malaria in pregnancy and small newborns: A cross-sectional study.PLOS global public health · 2025Article
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Cord Blood FGF-21 and GDF-15 Levels Are Affected by Maternal Exposure to Moderate to Severe Anemia and Malaria.Journal of the Endocrine Society · 2023Article
- Fetal macrosomia, fetal insulin, and insulin-like growth factor- 1 among neonates in Lagos, Nigeria: A case-control study.PloS one · 2022Article
- Suboptimal Intermittent Preventive Treatment in Pregnancy (IPTp) is Associated With an Increased Risk of Submicroscopic Plasmodium falciparum Infection in Pregnant Women: A Prospective Cohort Study in Benin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Dynamics of Submicroscopic Plasmodium falciparum Infections Throughout Pregnancy: A Preconception Cohort Study in Benin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Impact of the use and efficacy of long lasting insecticidal net on malaria infection during the first trimester of pregnancy - a pre-conceptional cohort study in southern Benin.BMC public health · 2018Article
- Antenatal Practices Ineffective at Prevention of Plasmodium falciparum Malaria during Pregnancy in a Sub-Saharan Africa Region, Nigeria.Tropical medicine and infectious disease · 2017Article
- Interleukin-10 and soluble tumor necrosis factor receptor II are potential biomarkers ofBiomarker research · 2017Article
- Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport.PLoS pathogens · 2013Article
- Malaria in pregnancy.Mediterranean journal of hematology and infectious diseases · 2013Article
- Hearing of neonates without risk indicators for hearing loss and use of antimalarial drugs during pregnancy: a historical cohort study in the Northern Region of Brazil.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMalaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been studied. The study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size.
methodsDuring pregnancy, anthropometric measurements, blood film for malaria parasites and assays for lipids, glucose, insulin and TNF were obtained from 467 mothers and these analytes and insulin-like growth factor-I (IGF-I) were obtained from cord blood of 187 babies.
resultsOverall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size. Mothers with malaria had significantly lower cholesterol (total, HDL and LDL) and higher TNF, but no difference in triglyceride. In contrast, there was no effect of maternal malaria on cord blood lipids, but the median (range) cord IGF-I was significantly lower in babies whose mothers had malaria: 60.4 (24, 145) μg/L, versus no malaria: 76.5 (24, 150) μg/L, p = 0.03. On regression analysis, the key determinants of birth weight included maternal total cholesterol, malarial status and cord insulin and IGF-I.
conclusionsMalaria in pregnancy was common and associated with reduced birth size, lower maternal lipids and higher TNF. In the setting of endemic malaria, maternal total cholesterol during pregnancy and cord blood insulin and IGF-I levels are potential biomarkers of foetal growth and birth size.
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