ReviewOrphanet journal of rare diseases2012
Pulmonary langerhans cell histiocytosis.
Review in Orphanet journal of rare diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pulmonary langerhans cell histiocytosis secondary to Marijuana use: a case report and systematic review of the literature.BMC pulmonary medicine · 2025Pooled it
- Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease.Blood · 2014Guideline
- Sotatercept in Pulmonary Langerhans Cell Histiocytosis-Associated Pulmonary Hypertension: A Case Series and Systematic Review.Pulmonary circulation · 2026Review
- Pulmonary langerhans cell histiocytosis following resection of lung adenocarcinoma: a case report and diagnostic challenges.American journal of cancer research · 2026Article
- Impact of Sex on Lung Function in Adult Langerhans Cell Histiocytosis.Life (Basel, Switzerland) · 2025Article
- Review
- Polyostotic Langerhans cell histiocytosis presenting as halitosis in a 24-year-old man: a case report.Journal of medical case reports · 2025Article
- Features of Lung Cyst in Birt-Hogg-Dubé Syndrome from Patients with Multiple Lung Cysts.Tuberculosis and respiratory diseases · 2025Article
- From diagnostic biopsy to bullectomy: A case of progressive complications in pulmonary langerhans cell histiocytosis.Respiratory medicine case reports · 2025Article
- Non-metastatic causes of multiple pulmonary nodules.Insights into imaging · 2024Article
- Posterior Instrumentation without Curettage Promotes Rapid Restoration of Adult Spinal Langerhans Cell Histiocytosis.Spine surgery and related research · 2024Article
- Pulmonary Langerhans cell histiocytosis presenting as an uncommon mass in the lung: A rare case report and literature review.Clinical case reports · 2024Article
- Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis.Journal of personalized medicine · 2024Review
- Recurrent pneumothoraces in a patient with pulmonary Langerhans cell histiocytosis accompanied with unexpected histological changes.Archive of clinical cases · 2024Article
- Case of pulmonary Langerhans cell histiocytosis presenting as ground-glass opacity in the lower lung.Respiratory medicine case reports · 2024Article
- Localized Synchronous Pulmonary Langerhans Cell Sarcoma and Langerhans Cell Histiocytosis.Annals of thoracic surgery short reports · 2023Article
- Evaluation of the Interstitial Histological Lesions in Pulmonary Langerhans Cell Histiocytosis.Turk patoloji dergisi · 2023Article
- Langerhans cell histiocytosis in adolescent patients: a single-centre retrospective study.Orphanet journal of rare diseases · 2022Article
- Pulmonary Langerhans cell histiocytosis and multiple system involvement: A case report.World journal of clinical cases · 2021Article
- Is the combination of bilateral pulmonary nodules and mosaic attenuation on chest CT specific for DIPNECH?Orphanet journal of rare diseases · 2021Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary Langerhans Cell Histiocytosis (PLCH) is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. While the overwhelming majority of patients are smokers, mechanisms by which smoking induces this disease are not known, but likely involve a combination of events resulting in enhanced recruitment and activation of Langerhans cells in small airways. Bronchiolar inflammation may be accompanied by variable lung interstitial and vascular involvement. While cellular inflammation is prominent in early disease, more advanced stages are characterized by cystic lung destruction, cicatricial scarring of airways, and pulmonary vascular remodeling. Pulmonary function is frequently abnormal at presentation. Imaging of the chest with high resolution chest CT scanning may show characteristic nodular and cystic abnormalities. Lung biopsy is necessary for a definitive diagnosis, although may not be required in instances were imaging findings are highly characteristic. There is no general consensus regarding the role of immunosuppressive therapy in smokers with PLCH. All smokers must be counseled on the importance of smoking cessation, which may result in regression of disease and obviate the need for systemic immunosuppressive therapy. The prognosis for most patients is relatively good, particularly if longitudinal lung function testing shows stability. Complications like pneumothoraces and secondary pulmonary hypertension may shorten life expectancy. Patients with progressive disease may require lung transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.