ArticleMicrocirculation (New York, N.Y. : 1994)2012
Microvascular flow modeling using in vivo hemodynamic measurements in reconstructed 3D capillary networks.
Article in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Predicting red blood cell transport and capillary hemodynamics in angiogenic and tumor vascular networks in silico.Biophysical journal · 2025Article
- Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model.Scientific reports · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- Hyperinsulinemia does not cause de novo capillary recruitment in rat skeletal muscle.Microcirculation (New York, N.Y. : 1994) · 2020Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Methods to label, image, and analyze the complex structural architectures of microvascular networks.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Capillary Network Morphometry of Pig Soleus Muscle Significantly Changes in 24 Hours After Death.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Rebuttal from David C. Poole.The Journal of physiology · 2014Article
- CrossTalk opposing view: De novo capillary recruitment in healthy muscle is not necessary to explain physiological outcomes.The Journal of physiology · 2014Article
- Skeletal muscle capillary function: contemporary observations and novel hypotheses.Experimental physiology · 2013Review
- Comparison of generated parallel capillary arrays to three-dimensional reconstructed capillary networks in modeling oxygen transport in discrete microvascular volumes.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Oxygen transport in the microcirculation and its regulation.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Modeling steady state SO2-dependent changes in capillary ATP concentration using novel O2 micro-delivery methods.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe describe a systematic approach to modeling blood flow using reconstructed capillary networks and in vivo hemodynamic measurements. Our goal was to produce flow solutions that represent convective O(2) delivery in vivo.
methodsTwo capillary networks, I and II (84 × 168 × 342 and 70 × 157 × 268 μm(3)), were mapped using custom software. Total network red blood cell supply rate (SR) was calculated from in vivo data and used as a target metric for the flow model. To obtain inlet hematocrits, mass balances were applied recursively from downstream vessels. Pressure differences across the networks were adjusted to achieve target SR. Baseline flow solutions were used as inputs to existing O(2) transport models. To test the impact of flow redistribution, asymmetric flow solutions (Asym) were generated by applying a ± 20% pressure change to network outlets.
resultsAsym solutions produced a mean absolute difference in SR per capillary of 27.6 ± 33.3% in network I and 33.2 ± 40.1% in network II vs. baseline. The O(2) transport model calculated mean tissue PO(2) of 28.2 ± 4.8 and 28.1 ± 3.5 mmHg for baseline and 27.6 ± 5.2 and 27.7 ± 3.7 mmHg for Asym.
conclusionsThis outcome illustrates that moderate changes in flow distribution within a capillary network have little impact on tissue PO(2) provided that total SR remains unchanged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.