ArticleBMC neuroscience2012
Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations.
Article in BMC neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Delivery of Apical Mesenchymal Stem Cells into Root Canals of Mature Teeth.Journal of dental research · 2015Trial
- Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion.bioRxiv : the preprint server for biology · 2024Article
- Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets.Scientific reports · 2023Article
- Trigeminal sensory nerve patterns in dentine and their responses to attrition in rat molars.Archives of oral biology · 2021Article
- Somatosensory innervation of healthy human oral tissues.The Journal of comparative neurology · 2021Article
- Glia and Orofacial Pain: Progress and Future Directions.International journal of molecular sciences · 2021Review
- Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart.Journal of anatomy · 2021Article
- Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- 3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy.Scientific reports · 2019Article
- Ion Channels Involved in Tooth Pain.International journal of molecular sciences · 2019Review
- The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain.International journal of molecular sciences · 2019Review
- Nociceptive and sympathetic innervations in the abaxial part of the cranial horn of the equine medial meniscus: an immunohistochemical approach.Journal of anatomy · 2016Article
- Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study.Clinical oral investigations · 2016Article
- Mechanisms of sodium channel clustering and its influence on axonal impulse conduction.Cellular and molecular life sciences : CMLS · 2016Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe dental pulp is a common source of pain and is used to study peripheral inflammatory pain mechanisms. Results show most fibers are unmyelinated, yet recent findings in experimental animals suggest many pulpal afferents originate from fibers that are myelinated at more proximal locations. Here we use the human dental pulp and confocal microscopy to examine the staining relationships of neurofilament heavy (NFH), a protein commonly expressed in myelinated afferents, with other markers to test the possibility that unmyelinated pulpal afferents originate from myelinated axons. Other staining relationships studied included myelin basic protein (MBP), protein gene product (PGP) 9.5 to identify all nerve fibers, tyrosine hydroxylase (TH) to identify sympathetic fibers, contactin-associated protein (caspr) to identify nodal sites, S-100 to identify Schwann cells and sodium channels (NaChs).
resultsResults show NFH expression in most PGP9.5 fibers except those with TH and include the broad expression of NFH in axons lacking MBP. Fibers with NFH and MBP show NaCh clusters at nodal sites as expected, but surprisingly, NaCh accumulations are also seen in unmyelinated fibers with NFH, and in fibers with NFH that lack Schwann cell associations.
conclusionsThe expression of NFH in most axons suggests a myelinated origin for many pulpal afferents, while the presence of NaCh clusters in unmyelinated fibers suggests an inherent capacity for the unmyelinated segments of myelinated fibers to form NaCh accumulations. These findings have broad implications on the use of dental pulp to study pain mechanisms and suggest possible novel mechanisms responsible for NaCh cluster formation and neuronal excitability.
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