Trial reportExperimental and clinical psychopharmacology2012
Understanding naltrexone mechanism of action and pharmacogenetics in Asian Americans via behavioral economics: a preliminary study.
Trial report in Experimental and clinical psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Experimental manipulations of behavioral economic demand for addictive commodities: a meta-analysis.Addiction (Abingdon, England) · 2020Pooled it
- Sensitivity of hypothetical purchase task indices when studying substance use: A systematic literature review.Preventive medicine · 2019Pooled it
- Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis.Addiction biology · 2019Pooled it
- Examining the effects of varenicline and naltrexone on delay discounting among individuals with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Trial
- Behavioral economic analysis of topiramate pharmacotherapy for alcohol: a placebo-controlled investigation of effects on alcohol reinforcing value and delayed reward discounting.Psychopharmacology · 2022Trial
- Influence of n-acetylcysteine maintenance on the pharmacodynamic effects of oral ethanol.Pharmacology, biochemistry, and behavior · 2020Trial
- Influence of phendimetrazine maintenance on the reinforcing, subjective, performance, and physiological effects of intranasal cocaine.Psychopharmacology · 2019Trial
- Behavioral economic predictors of brief alcohol intervention outcomes.Journal of consulting and clinical psychology · 2015Trial
- Increased behavioral economic demand and craving for alcohol following a laboratory alcohol challenge.Addiction (Abingdon, England) · 2015Trial
- Blocking opioids attenuates physical warmth-induced feelings of social connection.Emotion (Washington, D.C.) · 2015Trial
- Hypothetical food purchase tasks and eating behavior: A systematized review and future directions.Journal of the experimental analysis of behavior · 2026Review
- Why get high? Coping and enjoyment motives mediate elevated cannabis demand and cannabis-related outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Sex differences in the relationship between cannabis use motives and cannabis craving in daily life in emerging adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Alcohol demand assessed daily as a predictor of same day drinking.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Translational models of addiction phenotypes to advance addiction pharmacotherapy.Annals of the New York Academy of Sciences · 2023Review
- Change in alcohol demand following a brief intervention predicts change in alcohol use: A latent growth curve analysis.Alcoholism, clinical and experimental research · 2022Article
- Cannabis Use Disorder: A Behavioral Economic Perspective.Current addiction reports · 2022Article
- Craving, stimulation, and sedation as predictors of alcohol demand under intoxication.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Intravenous Alcohol Administration Selectively Decreases Rate of Change in Elasticity of Demand in Individuals With Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2020Article
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A behavioral economic approach to understanding the relative value of alcohol may be useful for advancing medication development for alcoholism. Naltrexone is a heavily researched and moderately effective treatment for alcohol dependence making it a good candidate for a proof-of-concept study of behavioral economics and alcoholism pharmacotherapy. This study examines naltrexone efficacy and pharmacogenetics in terms of the relative value of alcohol, assessed via demand curve analysis. Participants were 35 heavy drinking (AUDIT ≥8) Asian Americans. A within-subjects cross-over medication design was used along with an intravenous alcohol challenge completed after 4 days of both naltrexone and placebo. At baseline and BrAC = 0.06g/dl, participants completed an Alcohol Purchase Task, which assessed estimated alcohol consumption along escalating prices. Behavioral economic demand curve analysis yielded measures of intensity, elasticity, maximum expenditure (O(max)), proportionate price insensitivity (P(max)) and breakpoint. Compared to placebo, naltrexone significantly reduced intensity, O(max) and breakpoint. There were also trend-level medication effects on P(max). BrAC was associated with increases in P(max) and breakpoint. A significant naltrexone × OPRM1 genotype interaction was observed for intensity of demand. The present study extends the literature on naltrexone's mechanisms through the application of a novel behavioral economic paradigm. These results indicate that naltrexone reduces several indices of demand for alcohol. This preliminary report provides further evidence for the effectiveness of naltrexone and supports the utility of a behavioral economic approach to alcoholism pharmacotherapy development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.