ReviewAnnual review of public health2012
Early intervention to reduce the global health and economic burden of major depression in older adults.
Review in Annual review of public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07113548 (PERSONAE), which is not on this map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PERSONAE: a Personalized Adaptation of Stepped Care Internet-based Cognitive Behavioral Therapy for Depression - A Randomized Controlled Trial
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors and risk factors for suicide in late-life depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Placebo response rates and potential modifiers in double-blind randomized controlled trials of second and newer generation antidepressants for major depressive disorder in children and adolescents: a systematic review and meta-regression analysis.European child & adolescent psychiatry · 2020Pooled it
- Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies.The British journal of psychiatry : the journal of mental science · 2013Pooled it
- Effects of change in dysfunctional beliefs in avatar-based cognitive therapy for depressive symptoms: a randomized parallel trial.Scientific reports · 2025Trial
- Effectiveness of an age-modified mindfulness-based cognitive therapy (MBCT) in improving mental health in older people with depressive symptoms: a non-randomised controlled trial.BMC complementary medicine and therapies · 2025Trial
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- Effectiveness of Behavioral Activation in Treating Thai Older Adults with Subthreshold Depression Residing in the Community.Clinical interventions in aging · 2020Trial
- Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial.JAMA psychiatry · 2019Trial
- Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial.BMC psychiatry · 2016Trial
- Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women.The British journal of psychiatry : the journal of mental science · 2015Trial
- Effects of problem solving therapy on mental health outcomes in family caregivers of persons with a new diagnosis of mild cognitive impairment or early dementia: a randomized controlled trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Trial
- Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention.The American journal of psychiatry · 2014Trial
- Village doctor-assisted case management of rural patients with schizophrenia: protocol for a cluster randomized control trial.Implementation science : IS · 2014Trial
- Do Grape- and Wine-Derived (Poly)Phenols Contribute to the Hallmarks of Healthy Brain Ageing?Nutrients · 2026Review
- Sex-specific global, regional and national burden of dysthymia and major depression disorder in older adults from 1990 to 2021: a systematic analysis of the global burden of disease 2021 study.European archives of psychiatry and clinical neuroscience · 2026Article
- Trends in depression in the European population aged 50 years and older by geographic region.American journal of epidemiology · 2026Article
- Prevalence and determinants of social frailty among community-dwelling empty-nest older adults in China.Frontiers in public health · 2026Article
- Changes in the risk of depression in older adults in Poland from 2010 to 2019: results of two nationwide surveys.BMC geriatrics · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Randomized trials for selective and indicated prevention of depression in both mixed-aged and older adult samples, conducted in high-income countries (HICs), show that rates of incident depression can be reduced by 20-25% over 1-2 years through the use of psychoeducational and psychological interventions designed to increase protective factors. Recurrence of major depression can also be substantially reduced through both psychological and psychopharmacological strategies. Additional research is needed, however, to address the specific issues of depression prevention in older adults in low- and middle-income countries (LMICs). The growing number of older adults globally, as well as workforce issues and the expense of interventions, makes it important to develop rational, targeted, and cost-effective risk-reduction strategies. In our opinion, one strategy to address these issues entails the use of lay health counselors (LHCs), a form of task shifting already shown to be effective in the treatment of common mental disorders in LMICs. We suggest in this review that the time is right for research into the translation of depression-prevention strategies for use in LMICs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.