ArticleNutrition and cancer2012
Association of dietary quercetin with reduced risk of proximal colon cancer.
Article in Nutrition and cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies.Nutrients · 2018Pooled it
- Index-based dietary patterns and colorectal cancer risk: a systematic review.Advances in nutrition (Bethesda, Md.) · 2015Pooled it
- Dietary flavonoid intake and risk of stomach and colorectal cancer.World journal of gastroenterology · 2013Pooled it
- Plant Extracts fromInternational journal of molecular sciences · 2026Article
- Low-Dose Quercetin Dephosphorylates AKT and Suppresses Proteins Related to Migration in Human Metastatic Uveal Melanoma Cells.Life (Basel, Switzerland) · 2025Article
- Targeting colorectal cancer using dietary flavonols.Cancer innovation · 2024Review
- Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells.International journal of molecular sciences · 2023Article
- Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer.Chinese journal of integrative medicine · 2022Review
- Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?World journal of gastrointestinal oncology · 2022Review
- Associations of Evolutionary-Concordance Diet and Lifestyle Pattern Scores with Incident, Sporadic Colorectal Adenoma in a Pooled Case-Control Study.Nutrition and cancer · 2022Article
- A Review on Dietary Intervention in Obesity Associated Colon CancerAsian Pacific journal of cancer prevention : APJCP · 2019Review
- Flavonoids and Colorectal Cancer Prevention.Antioxidants (Basel, Switzerland) · 2018Review
- Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer.Journal of cellular physiology · 2018Review
- Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families.Nutrients · 2018Article
- Predictors of the Healthy Eating Index and Glycemic Index in Multi-Ethnic Colorectal Cancer Families.Nutrients · 2018Article
- Nutritional Correlates of Human Oral Microbiome.Journal of the American College of Nutrition · 2017Article
- Association between Nutrient Intake and Metabolic Syndrome in Patients with Colorectal Cancer.Clinical nutrition research · 2017Article
- Pretreatment serum xanthophyll concentrations as predictors of head and neck cancer recurrence and survival.Head & neck · 2016Article
- Kimchi and Other Widely Consumed Traditional Fermented Foods of Korea: A Review.Frontiers in microbiology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Quercetin is a flavonol that appears to be protective against several cancers, but its possible role in prevention of colorectal cancer is not yet well studied. We evaluated dietary intakes of quercetin and risk of colorectal cancer in a large case-control study conducted in metropolitan Detroit, Michigan (N = 2664). The protective effects of quercetin intake, as assessed by a food frequency questionnaire, were confined to risk of proximal colon cancer. Stratified analyses showed that the protective effects of quercetin on risk of proximal colon cancer were significant only when fruit intake or the Healthy Eating Index score was high, or when tea intake was low, with odds ratios (OR) for the highest vs. the lowest quartile of 0.49, 0.44, and 0.51, respectively. Increased quercetin intake had no protective effects when tea intake was high. Interestingly, increased intake of quercetin was associated with increased risk of distal colon cancer when total fruit intake was low (OR for the highest vs. the lowest quartile = 1.99). These results suggest that quercetin can have disparate effects on colon cancer risk depending on whether dietary intakes of fruit or tea are high, and that quercetin had protective effects only on proximal, not distal, colon cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.