ArticleScientific reports2012
Evaluating the viscoelastic properties of tissue from laser speckle fluctuations.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Non-Destructive Assessment of Dentin Composite Bond Integrity using Laser Speckle Imaging and Machine Learning Regression.Annals of biomedical engineering · 2026Article
- Wide-field and non-invasive imaging of brain tumours with scattered light techniques.Biomedical optics express · 2026Article
- Laser speckle particle sizer (SPARSE) informs the size distribution of tissue granularities.Science advances · 2025Article
- Optical, contact-free assessment of brain tissue stiffness and neurodegeneration.Biomedical optics express · 2025Article
- Passive high-frequency microrheology of blood.Soft matter · 2022Article
- Technological perspectives on laser speckle micro-rheology for cancer mechanobiology research.Journal of biomedical optics · 2021Article
- In-vivo mechanical characterization of coronary atherosclerotic plaques in living swine using intravascular laser speckle imaging.Biomedical optics express · 2021Article
- Non-invasiveBiomedical optics express · 2020Article
- Comprehensive Blood Coagulation Profiling in Patients Using iCoagLab: Comparison Against Thromboelastography.Thrombosis and haemostasis · 2020Article
- Tutorial on laser speckle rheology: technology, applications, and opportunities.Journal of biomedical optics · 2020Review
- Optical elastography and tissue biomechanics.Journal of biomedical optics · 2019Article
- Morphing of liquid crystal surfaces by emergent collectivity.Nature communications · 2019Article
- Comprehensive Coagulation Profiling at the Point-of-Care Using a Novel Laser-Based Approach.Seminars in thrombosis and hemostasis · 2019Article
- Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing.Frontiers in bioengineering and biotechnology · 2019Review
- Analysis of blood coagulation process based on fractality and dynamic characteristic of laser speckle pattern.Journal of biomedical optics · 2018Article
- Biomechanical assessment of myocardial infarction using optical coherence elastography.Biomedical optics express · 2018Article
- Article
- Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towardsBiomedical optics express · 2017Article
- Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor.Scientific reports · 2017Article
- Evaluating platelet aggregation dynamics from laser speckle fluctuations.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Most pathological conditions such as atherosclerosis, cancer, neurodegenerative, and orthopedic disorders are accompanied with alterations in tissue viscoelasticity. Laser Speckle Rheology (LSR) is a novel optical technology that provides the invaluable potential for mechanical assessment of tissue in situ. In LSR, the specimen is illuminated with coherent light and the time constant of speckle fluctuations, τ, is measured using a high speed camera. Prior work indicates that τ is closely correlated with tissue microstructure and composition. Here, we investigate the relationship between LSR measurements of τ and sample mechanical properties defined by the viscoelastic modulus, G*. Phantoms and tissue samples over a broad range of viscoelastic properties are evaluated using LSR and conventional mechanical testing. Results demonstrate a strong correlation between τ and |G*| for both phantom (r = 0.79, p <0.0001) and tissue (r = 0.88, p<0.0001) specimens, establishing the unique capability of LSR in characterizing tissue viscoelasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.