Evidence map›Paper›PMID 22427914›Full record

ArticlePloS one2012

Rhodococcus bacteremia in cancer patients is mostly catheter related and associated with biofilm formation.

Fadi Al Akhrass, Iba Al Wohoush, Anne-Marie Chaftari, Ruth Reitzel, Ying Jiang, Mahmoud Ghannoum, Jeffrey Tarrand, Ray Hachem, Issam Raad

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Complementary and Alternative Therapies for Psoriasis.Archives of dermatological research · 2024
    Pooled it
  2. Phenotypical and molecular characterization of Rhodococcus equi isolated from foals in the Agreste region of Pernambuco - Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. IntratumorCurrent research in microbial sciences · 2025
    Article
  4. Rising prevalence and drug resistance ofFrontiers in cellular and infection microbiology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Phenotypic Characterization ofPathogens (Basel, Switzerland) · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Epidemiology of infections in cancer patients.Cancer treatment and research · 2014
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fadi Al AkhrassDepartment of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Iba Al Wohoush
Anne-Marie Chaftari
Ruth Reitzel
Ying Jiang
Mahmoud Ghannoum
Jeffrey Tarrand
Ray Hachem
Issam Raad
The University of Texas MD Anderson Cancer Center · USCase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhodococcus is an emerging cause of opportunistic infection in immunocompromised patients, most commonly causing cavitary pneumonia. It has rarely been reported as a cause of isolated bacteremia. However, the relationship between bacteremia and central venous catheter is unknown. Between 2002 and 2010, the characteristics and outcomes of seventeen cancer patients with Rhodococcus bacteremia and indwelling central venous catheters were evaluated. Rhodococcus bacteremias were for the most part (94%) central line-associated bloodstream infection (CLABSI). Most of the bacteremia isolates were Rhodococcus equi (82%). Rhodococcus isolates formed heavy microbial biofilm on the surface of polyurethane catheters, which was reduced completely or partially by antimicrobial lock solution. All CLABSI patients had successful response to catheter removal and antimicrobial therapy. Rhodococcus species should be added to the list of biofilm forming organisms in immunocompromised hosts and most of the Rhodococcus bacteremias in cancer patients are central line associated.

Indexed as

Immunocompromised HostRhodococcus equiBacteremiaBiofilmsCatheterization, Central VenousHumansMicroscopy, Electron, ScanningNeoplasms

Identifiers

PMID22427914
PMCPMC3302794
OpenAlexW2151715764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.