ArticlePloS one2012
Effects of anesthetic agents on brain blood oxygenation level revealed with ultra-high field MRI.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Diurnal differences in cerebral microvascular blood flow and oxygen delivery across brain regions in awake mice.Neurophotonics · 2026Article
- Promising Cerebral Blood Flow Enhancers in Acute Ischemic Stroke.Translational stroke research · 2023Review
- Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain.Frontiers in neuroscience · 2022Article
- Article
- Cerebrovascular MRI in the mouse without an exogenous contrast agent.Magnetic resonance in medicine · 2020Article
- Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.Frontiers in neuroinformatics · 2019Review
- Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ketamine and Xylazine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Light controls cerebral blood flow in naive animals.Nature communications · 2017Article
- Article
- Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents.Applied magnetic resonance · 2015Article
- Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.NeuroImage. Clinical · 2015Article
- Sedation agents differentially modulate cortical and subcortical blood oxygenation: evidence from ultra-high field MRI at 17.2 T.PloS one · 2014Article
- Functional connectivity fMRI in mouse brain at 7T using isoflurane.Journal of neuroscience methods · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During general anesthesia it is crucial to control systemic hemodynamics and oxygenation levels. However, anesthetic agents can affect cerebral hemodynamics and metabolism in a drug-dependent manner, while systemic hemodynamics is stable. Brain-wide monitoring of this effect remains highly challenging. Because T(2)*-weighted imaging at ultra-high magnetic field strengths benefits from a dramatic increase in contrast to noise ratio, we hypothesized that it could monitor anesthesia effects on brain blood oxygenation. We scanned rat brains at 7T and 17.2T under general anesthesia using different anesthetics (isoflurane, ketamine-xylazine, medetomidine). We showed that the brain/vessels contrast in T(2)*-weighted images at 17.2T varied directly according to the applied pharmacological anesthetic agent, a phenomenon that was visible, but to a much smaller extent at 7T. This variation is in agreement with the mechanism of action of these agents. These data demonstrate that preclinical ultra-high field MRI can monitor the effects of a given drug on brain blood oxygenation level in the absence of systemic blood oxygenation changes and of any neural stimulation.
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