Evidence map›Paper›PMID 22427806›Full record

ArticlePloS one2012

Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens.

Cynthia J Snider, Stephen R Cole, Kiprotich Chelimo, Peter Odada Sumba, Pia D M Macdonald, Chandy C John, Steven R Meshnick, Ann M Moormann

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. A New Hope for CD56Frontiers in cellular and infection microbiology · 2020
    Article
  6. The Association between the Comprehensive Epstein-Barr Virus Serologic Profile and Endemic Burkitt Lymphoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Burkitt's lymphoma of the jaws in the Amazon region of Brazil.Medicina oral, patologia oral y cirugia bucal · 2014
    Article
  14. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Cynthia J SniderDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Stephen R Cole
Kiprotich Chelimo
Peter Odada Sumba
Pia D M Macdonald
Chandy C John
Steven R Meshnick
Ann M Moormann
University of North Carolina at Chapel Hill · USKenya Medical Research Institute · KEUniversity of Massachusetts Chan Medical School · USUniversity of Minnesota Medical Center · US

Funding

Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Malaria transmission and immunity in highland KenyaU01AI056270 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JOHN, CHANDY C. · 2005 to 2009
$2.9M
T Cell Immunity in Endemic Burkitt LymphomaR01CA134051 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOORMANN, ANN M · 2008 to 2012
$2.3M
Immunologic Studies of Endemic Burkitt's LymphomaK08AI051565 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI MOORMANN, ANN M · 2002 to 2006
$542k
IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAK08AI001572 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI JOHN, CHANDY C · 1999 to 2002
$350k
NCI NIH HHS CA134051NCI NIH HHS R01 CA134051NIAID NIH HHS 5-T32-AI070114-03NIAID NIH HHS AI01572NIAID NIH HHS AI056270NIAID NIH HHS K08 AI051565NIAID NIH HHS K08 AI51565NIAID NIH HHS T32 AI070114NIAID NIH HHS U01 AI056270
6 · The paper itself

Abstract

Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.

Indexed as

AdolescentBurkitt LymphomaCD8-Positive T-LymphocytesChildChild, PreschoolCoinfectionEnzyme-Linked Immunospot AssayHerpesvirus 4, HumanHumansImmunity, CellularInfantInterferon-gammaKenyaMalaria, FalciparumPrevalenceRecurrenceInterferon-gamma

Identifiers

PMID22427806
PMCPMC3299627
OpenAlexW2008058286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.