ArticleArchives of medical science : AMS2010
The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema - an experimental study.
Article in Archives of medical science : AMS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Case Report: Re-expansion pulmonary edema following a pneumothorax drainage in a patient with H1N1 andFrontiers in medicine · 2025Article
- Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Adenocarcinoma masked by re-expansion pulmonary edema after chest drainage for pneumothorax.Thoracic cancer · 2019Article
- Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.Journal of cellular and molecular medicine · 2019Article
- A common gesture with a rare but potentially severe complication: Re-expansion pulmonary edema following chest tube drainage.Respiratory medicine case reports · 2019Article
- An easier and safe affair, pleural drainage with ultrasound in critical patient: a technical note.Critical ultrasound journal · 2018Article
- Hypoxemia after pneumothorax exsufflation: a case report.The Pan African medical journal · 2017Article
- Comparative investigation of antioxidant activity of human serum blood by amperometric, voltammetric and chemiluminescent methods.Archives of medical science : AMS · 2016Article
- An uncommon complication of a common clinical scenario: exploring reexpansion pulmonary edema with a case report and literature review.Journal of community hospital internal medicine perspectives · 2016Review
- Reexpansion pulmonary edema after chest drainage for pneumothorax: A case report and literature overview.Respiratory medicine case reports · 2015Article
- Whole-body cryostimulation and oxidative stress in rowers: the preliminary results.Archives of medical science : AMS · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe investigated the role of oxidative stress in the pathogenesis of reexpansion pulmonary edema (RPE) and effect of alpha-lipoic acid (ALA) in the prevention of RPE. MATERIAL AND
methodsThere were 4 groups consisting of 10 rats in each group; control group (CG), α-lipoic acid group (ALAG), reexpansion pulmonary edema group (RPEG), reexpansion pulmonary edema plus α-lipoic acid group (RPE + ALAG). In all the groups, all rats were sacrificed 2 hours after the reexpansion of lungs. To indicate oxidative stress malondialdehyde (MDA), and to indicate antioxidant status superoxide dismutase (SOD), catalase (CAT) and glutathione peroxides (GPx) were measured in the lungs of rats.
resultsMean MDA value was lower in CG (7.02 ±0.14) and in ALAG (6.95 ±0.11) than the other groups (p = 0.001). It was highest in RPEG (8.89 ±0.21) (p = 0.001). It was lower in RPE + ALA G (7.21 ±0.32) than RPEG (p = 0.001). Antioxidant levels: GPx (37.21 ±3.01), CAT (2.87 ±0.14) and SOD (100.12 ±12.39) were lowest in RPEG among all groups (p = 0.001). These values were GPx (45.21 ±3.54), CAT (3.24 ±0.21) and SOD (172.36 ±15.48) in RPE + ALA G and were greater than those of RPEG (p = 0.001). While normal pulmonary parenchyma was seen in 2 rats in RPE + ALAG, it was not seen in RPEG. Pulmonary edema was seen in 1 rat in RPE + ALAG; however, it was seen in 3 in RPEG.
conclusionsOxidative stress might have an important role in the pathogenesis of RPE. In addition, ALA treatment might contribute in preventing RPE.
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