ArticleCancer management and research2012
Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?
Article in Cancer management and research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- The role of TLRs (microbe recognition receptor) in gastric cancer: An update.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Article
- NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma.Cancer medicine · 2017Article
- No genetic relationship betweenOncoTargets and therapy · 2017Article
- The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease.Critical reviews in immunology · 2016Review
- Editorial: Pattern Recognition Receptors and Cancer.Frontiers in immunology · 2015Article
- Emerging significance of NLRs in inflammatory bowel disease.Inflammatory bowel diseases · 2014Review
- Correlation between genetic polymorphisms within IL-1B and TLR4 genes and cancer risk in a Russian population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Pattern recognition receptors and DNA repair: starting to put a jigsaw puzzle together.Frontiers in immunology · 2014Review
- Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis.Frontiers in immunology · 2014Review
- Cancer: A Tale of Aberrant PRR Response.Frontiers in immunology · 2014Review
- Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment.Breast cancer (Dove Medical Press) · 2013Review
- Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine.Cancer management and research · 2012Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like receptors. They are key sensors for a number of infectious agents, some of which are carcinogenic, and they launch an immune response against them. Inherited structural variation in genes encoding these receptors and proteins of their signaling pathways may affect their function, modulating cancer risk and features of cancer progression. Relevant malignancies, valuable gene polymorphisms, prime questions about future directions, and answers to these questions are analyzed in this review. It is possible to suggest that polymorphisms of genes encoding pattern recognition receptors and proteins of their signaling pathways may be associated with almost all cancer types, particularly with those in which carcinogenic infectious agents are responsible for the substantial share of cases (namely gastric cancer, colorectal cancer, liver cancer, cervical cancer, and nasopharyngeal carcinoma). The concept of selection of polymorphisms for further oncogenomic investigation, based on a combination of results from basic and epidemiological studies, is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.