ArticleThe Journal of infectious diseases2012
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.Clinical and experimental immunology · 2015Trial
- Tumor Necrosis Factor Receptor 2 Inhibits HIV-1 Infection by Blocking the Binding of gp120 to CD4.International journal of biological sciences · 2026Article
- HIV, Inflammation, and Immunometabolism: A Model of the Inflammatory Theory of Disease.Viruses · 2025Review
- Regulatory T Cells Kinetics in Immune Reconstitution Inflammatory Syndrome in HIV-Tuberculosis Co-Infected Individuals.Journal of molecular and clinical medicine · 2025Article
- HIV reservoir and premature aging: risk factors for aging-associated illnesses in adolescents and young adults with perinatally acquired HIV.PLoS pathogens · 2024Article
- Review
- The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence.PLoS pathogens · 2022Article
- Preterm Birth in Women With HIV: The Role of the Placenta.Frontiers in global women's health · 2022Review
- Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.Journal of virology · 2020Article
- Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.Frontiers in immunology · 2020Article
- HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells.PloS one · 2020Article
- Immune signatures for HIV-1 and HIV-2 induced CD4BMC infectious diseases · 2019Article
- Microbiome Dependent Regulation of TFrontiers in immunology · 2019Review
- Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.Frontiers in immunology · 2019Article
- Regulatory CD4Circulation · 2018Article
- Regulatory T cells in retroviral infections.PLoS pathogens · 2018Review
- Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells.Frontiers in immunology · 2018Article
- Regulatory T Cells As Potential Targets for HIV Cure Research.Frontiers in immunology · 2018Review
- Phenotypic characterization of regulatory T cells from antiretroviral-naive HIV-1-infected people.Immunology · 2017Article
- Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.Immunological reviews · 2017Review
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
Abstract
Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.