ArticleJournal of bacteriology2012
Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Control of transcription elongation and DNA repair by alarmone ppGpp.Nature structural & molecular biology · 2023Article
- Article
- Pervasive Transcription-coupled DNA repair in E. coli.Nature communications · 2022Article
- Metagenomic analysis revealed a wide distribution of antibiotic resistance genes and biosynthesis of antibiotics in the gut of giant pandas.BMC microbiology · 2021Article
- Archaeal DNA Repair Mechanisms.Biomolecules · 2020Review
- Targeting evolution to inhibit antibiotic resistance.The FEBS journal · 2020Review
- Article
- Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions.Nature communications · 2019Article
- Mfd protects against oxidative stress in Bacillus subtilis independently of its canonical function in DNA repair.BMC microbiology · 2019Article
- Evaluation of E. coli inhibition by plain and polymer-coated silver nanoparticles.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- Mfd Protein and Transcription-Repair Coupling in Escherichia coli.Photochemistry and photobiology · 2017Review
- Transcription-coupled repair: an update.Archives of toxicology · 2016Review
- The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response.Scientific reports · 2016Article
- ppGpp couples transcription to DNA repair in E. coli.Science (New York, N.Y.) · 2016Article
- Article
- Rethinking transcription coupled DNA repair.Current opinion in microbiology · 2015Review
- UvrD helicase: an old dog with a new trick: how one step backward leads to many steps forward.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase.PloS one · 2015Article
- Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.Nucleic acids research · 2014Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription-coupled repair (TCR) is a cellular process by which some forms of DNA damage are repaired more rapidly from transcribed strands of active genes than from nontranscribed strands or the overall genome. In humans, the TCR coupling factor, CSB, plays a critical role in restoring transcription following both UV-induced and oxidative DNA damage. It also contributes indirectly to the global repair of some forms of oxidative DNA damage. The Escherichia coli homolog, Mfd, is similarly required for TCR of UV-induced lesions. However, its contribution to the restoration of transcription and to global repair of oxidative damage has not been examined. Here, we report the first direct study of transcriptional recovery following UV-induced and oxidative DNA damage in E. coli. We observed that mutations in mfd or uvrA reduced the rate that transcription recovered following UV-induced damage. In contrast, no difference was detected in the rate of transcription recovery in mfd, uvrA, fpg, nth, or polB dinB umuDC mutants relative to wild-type cells following oxidative damage. mfd mutants were also fully resistant to hydrogen peroxide (H(2)O(2)) and removed oxidative lesions from the genome at rates comparable to wild-type cells. The results demonstrate that Mfd promotes the rapid recovery of gene expression following UV-induced damage in E. coli. In addition, these findings imply that Mfd may be functionally distinct from its human CSB homolog in that it does not detectably contribute to the recovery of gene expression or global repair following oxidative damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.