ArticleInvestigative ophthalmology & visual science2012
The optic nerve head as a robust biomechanical system.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy.Investigative ophthalmology & visual science · 2022Article
- Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure.Life (Basel, Switzerland) · 2020Article
- Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice.Investigative ophthalmology & visual science · 2020Article
- Lamina Cribrosa Moves Anteriorly After Trabeculectomy in Myopic Eyes.Investigative ophthalmology & visual science · 2020Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
- Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure.Investigative ophthalmology & visual science · 2017Article
- What is a typical optic nerve head?Experimental eye research · 2016Article
- Use and Misuse of Laplace's Law in Ophthalmology.Investigative ophthalmology & visual science · 2016Review
- Translating ocular biomechanics into clinical practice: current state and future prospects.Current eye research · 2015Review
- Recent advances in OCT imaging of the lamina cribrosa.The British journal of ophthalmology · 2014Review
- Eye-specific IOP-induced displacements and deformations of human lamina cribrosa.Investigative ophthalmology & visual science · 2014Article
- In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm.Journal of the Royal Society, Interface · 2013Article
- A few good responses: which mechanical effects of IOP on the ONH to study?Investigative ophthalmology & visual science · 2012Article
- Ocular hemodynamics and glaucoma: the role of mathematical modeling.European journal of ophthalmologyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Purpose. Understanding the effects of IOP on the optic nerve head (ONH) is important in understanding glaucoma and ONH structure and function. The authors tested the hypothesis that the ONH is a robust biomechanical structure wherein various factors combine to produce a relatively stable response to IOP. Methods. The authors generated two populations of 100,000 ONH numerical models each with randomly selected values, but controlled distributions, either uniform or Gaussian, of ONH geometry and mechanical properties. The authors predicted the lamina cribrosa displacement (LCD), scleral canal expansion (SCE), and the stresses (forces) and deformations (strains) produced by a 10 mm Hg increase in IOP. The authors analyzed the distributions of the responses. Results. The responses were distributed nonuniformly, with the majority of the models having a response within a small region, often less than 30% of the size of the overall response region. This concentration of responses was more marked in the Gaussian population than in the uniform population. All the responses were positively skewed. Whether a particular case was typical or not depended on the response used for classification and on whether the decision was made using one-dimensional or two-dimensional criteria. Conclusions. Despite wide variations in ONH characteristics and responses to IOP, some responses were much more common than others. This supports conceiving of the eye as a robust structure, particularly for LCD and SCE, which is tolerant to variations in tissue geometry and mechanical properties. The authors also provide the first estimates of the typical mechanical response of the ONH to variations in IOP over a large population of ONHs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.