ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 122 citations in OpenAlex.
- Binge Alcohol Consumption Elevates Sympathetic Transduction to Blood Pressure: A Randomized Controlled Trial.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Aging enhances autonomic support of blood pressure in women.Hypertension (Dallas, Tex. : 1979) · 2014Trial
- The sympathetic baroreflex across the lifespan: Is loss of hysteresis a stop on the road to dysfunction?Experimental physiology · 2026Article
- Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Age and sex differences in blood pressure regulation: A focus on the vascular baroreflex limb.Physiological reports · 2025Article
- Sympathetic transduction to blood pressure in patients with chronic kidney disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- Impaired Neurocirculatory Control in Chronic Kidney Disease: New Evidence for Blunted Sympathetic Baroreflex and Reduced Sympathetic Transduction.Function (Oxford, England) · 2024Article
- Respiratory modulation of sympathetic transduction to blood pressure in health and type 2 diabetes.The Journal of physiology · 2024Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2024Article
- Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The sympathetic nervous system is critical for the beat-to-beat regulation of arterial blood pressure (BP). Although studies have examined age- and sex-related effects on BP control, findings are inconsistent and limited data are available in postmenopausal women. In addition, the majority of studies have focused on time-averaged responses without consideration for potential beat-to-beat alterations. Thus we examined whether the ability of muscle sympathetic nerve activity (MSNA) to modulate BP on a beat-to-beat basis is affected by age or sex. BP and MSNA were measured during supine rest in 40 young (20 men) and 40 older (20 men) healthy subjects. Beat-to-beat fluctuations in mean arterial pressure (MAP) were characterized for 15 cardiac cycles after each MSNA burst using signal averaging. The rise in MAP following an MSNA burst was similar between young men and women (+2.64 ± 0.3 vs. +2.57 ± 0.3 mmHg, respectively). However, the magnitude of the increase in MAP after an MSNA burst was reduced in older compared with young subjects (P < 0.05). Moreover, the attenuation of the pressor response was greater in older women (+1.20 ± 0.1 mmHg) compared with older men (+1.72 ± 0.2 mmHg; P < 0.05). Interestingly, in all groups, MAP consistently decreased after cardiac cycles without MSNA bursts (nonbursts) with the magnitude of fall greatest in older men. In summary, healthy aging is associated with an attenuated beat-to-beat increase in BP after a spontaneous MSNA burst, and this attenuation is more pronounced in postmenopausal women. Furthermore, our nonburst findings highlight the importance of sympathetic vasoconstrictor activity to maintain beat-to-beat BP, particularly in older men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.