ArticleThe Plant cell2012
Analysis of the developmental roles of the Arabidopsis gibberellin 20-oxidases demonstrates that GA20ox1, -2, and -3 are the dominant paralogs.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 232 citations in OpenAlex.
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- Anther and pollen thermotolerance: molecular mechanisms and implications for plant reproduction under heat stress.Planta · 2026Review
- Genome-wide identification and integrated analysis of gibberellin oxidase genes associated with branch angle and internode elongation in tea plants (Frontiers in plant science · 2026Article
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
- Systematic mutagenesis reveals dominant-minor paralog configurations in the riceFrontiers in plant science · 2026Article
- miR156-SPLs module regulates flowering and controls plant height by modulating gibberellin biosynthesis in citrus.Plant biotechnology journal · 2025Article
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- Article
- Allelic variations in GA20ox3 regulate fruit length and seed germination timing for high-altitude adaptation in Arabidopsis thaliana.Nature communications · 2025Article
- LoBLH6 interacts with LoMYB65 to regulate anther development through feedback regulation of gibberellin synthesis in lily.Horticulture research · 2025Article
- Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude.Science China. Life sciences · 2025Article
- Dwarfs standing tall: breeding towards the 'Yellow revolution' through insights into plant height regulation.Plant molecular biology · 2025Review
- Towards resilience: Transcriptional insights on flavonoid biosynthesis during peanut seed maturation phases.PloS one · 2025Article
- Genetic suppressor ofFrontiers in plant science · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
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Abstract
Gibberellin (GA) biosynthesis is necessary for normal plant development, with later GA biosynthetic stages being governed by multigene families. Arabidopsis thaliana contains five GA 20-oxidase (GA20ox) genes, and past work has demonstrated the importance of GA20ox1 and -2 for growth and fertility. Here, we show through systematic mutant analysis that GA20ox1, -2, and -3 are the dominant paralogs; their absence results in severe dwarfism and almost complete loss of fertility. In vitro analysis revealed that GA20ox4 has full GA20ox activity, but GA20ox5 catalyzes only the first two reactions of the sequence by which GA(12) is converted to GA(9). GA20ox3 functions almost entirely redundantly with GA20ox1 and -2 at most developmental stages, including the floral transition, while GA20ox4 and -5 have very minor roles. These results are supported by analysis of the gene expression patterns in promoter:β-glucuronidase reporter lines. We demonstrate that fertility is highly sensitive to GA concentration, that GA20ox1, -2, and -3 have significant effects on floral organ growth and anther development, and that both GA deficiency and overdose impact on fertility. Loss of GA20ox activity causes anther developmental arrest, with the tapetum failing to degrade. Some phenotypic recovery of late flowers in GA-deficient mutants, including ga1-3, indicated the involvement of non-GA pathways in floral development.
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Registered trials
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